Hana Joch

TL;DR: High glucose, via PKC signaling, induces oxidative stress and upregulation of COX-2, resulting in reduced NO availability and altered prostanoid profile.

TL;DR: Endothelial tissue factor induction by thrombin is regulated by Rho/Rho-kinase, Akt, and p38 MAP kinase, which provides new insights into the action of statins in acute coronary syndromes.

TL;DR: Thrombin suppresses eNOS and upregulates ECE-1 expression via Rho/ROCK and ERK pathway, respectively, and may be important for endothelial dysfunction in cardiovascular disease, particularly during acute coronary episodes.

TL;DR: Analysis of the efficiencies of transduction and the transport mechanisms of AAV type 2 (AAV-2) in different cell types, emphasizing endothelial cells, points to a more complex cell-type-specific mode ofTransduction of Aav-2 than previously appreciated.

TL;DR: Tacrolimus is less potent than sirolimus for inhibiting VSMC proliferation or migration, but exerts markedly less antiproliferative effects on EC compared with sIROlimus, and may represent a promising compound for the use in drug-eluting stents.