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Zhihong Yang

Researcher at University of Fribourg

Publications -  143
Citations -  12796

Zhihong Yang is an academic researcher from University of Fribourg. The author has contributed to research in topics: Endothelium & Vascular smooth muscle. The author has an hindex of 47, co-authored 125 publications receiving 11832 citations. Previous affiliations of Zhihong Yang include University Hospital of Basel & University of Bern.

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Threshold concentrations of endothelin-1 potentiate contractions to norepinephrine and serotonin in human arteries. A new mechanism of vasospasm?

TL;DR: To study whether low concentrations of endothelin-1 potentiate the effects of other vasoconstrictor hormones, suspended isolated human internal mammary and left anterior descending coronary artery rings in organ chambers for isometric tension recording.
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Rho GTPase/Rho kinase negatively regulates endothelial nitric oxide synthase phosphorylation through the inhibition of protein kinase B/Akt in human endothelial cells.

TL;DR: It is demonstrated that Rho/ROCK pathway negatively regulates eNOS phosphorylation through inhibition of PKB, whereas it downregulates eNos expression independent of P KB.
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Interaction between endothelin-1 and endothelium-derived relaxing factor in human arteries and veins.

TL;DR: EDRF inhibits endothelin-1-induced contractions, whereas the peptide specifically attenuates the effects of EDRF and nitrovasodilators in veins, which may be important in pathological conditions associated with increased levels of endotheli-1 and in veins used as coronary bypass grafts.
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Ectopic fat storage in heart, blood vessels and kidneys in the pathogenesis of cardiovascular diseases

TL;DR: Accumulation of fat around blood vessels (perivascular fat) may affect vascular function in a paracrine manner, as perivascularfat cells secrete vascular relaxing factors, proatherogenic cytokines and smooth muscle cell growth factors, which could mechanically contribute to the increased vascular stiffness seen in obesity.