H
Hanif Khalak
Researcher at Cornell University
Publications - 26
Citations - 6416
Hanif Khalak is an academic researcher from Cornell University. The author has contributed to research in topics: Gene & Single-nucleotide polymorphism. The author has an hindex of 16, co-authored 25 publications receiving 6154 citations. Previous affiliations of Hanif Khalak include Novartis & J. Craig Venter Institute.
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Journal ArticleDOI
The complete genome sequence of the gastric pathogen Helicobacter pylori
Jean-F. Tomb,Owen White,Anthony R. Kerlavage,Rebecca A. Clayton,Granger G. Sutton,Robert D. Fleischmann,Karen A. Ketchum,Hans-Peter Klenk,Steven R. Gill,Brian Dougherty,Karen E. Nelson,John Quackenbush,Lixin Zhou,Ewen F. Kirkness,Scott N. Peterson,Brendan J. Loftus,Delwood Richardson,Robert J. Dodson,Hanif Khalak,Anna Glodek,Keith McKenney,Lisa M. Fitzegerald,Norman H. Lee,Mark Raymond Adams,Erin Hickey,Douglas E. Berg,Jeanine D. Gocayne,Teresa Utterback,Jeremy Peterson,Jenny M. Kelley,Matthew D. Cotton,J. Weidman,Claire Fujii,Cheryl Bowman,Larry Watthey,Erik Wallin,William S. Hayes,Mark Borodovsky,Peter D. Karp,Hamilton O. Smith,Claire M. Fraser,J. Craig Venter +41 more
TL;DR: Sequence analysis indicates that H. pylori has well-developed systems for motility, for scavenging iron, and for DNA restriction and modification, and consistent with its restricted niche, it has a few regulatory networks, and a limited metabolic repertoire and biosynthetic capacity.
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Complete Genome Sequence of Treponema pallidum, the Syphilis Spirochete
Claire M. Fraser,Steven J. Norris,George M. Weinstock,Owen White,Granger G. Sutton,Robert J. Dodson,Michelle L. Gwinn,Erin Hickey,Rebecca A. Clayton,Karen A. Ketchum,Erica Sodergren,John M. Hardham,Michael P. McLeod,Steven L. Salzberg,Jeremy Peterson,Hanif Khalak,Delwood Richardson,Jerrilyn K. Howell,Monjula Chidambaram,Teresa Utterback,Lisa McDonald,Patricia Artiach,Cheryl Bowman,Matthew D. Cotton,Claire Fujii,Stacey Garland,Bonnie Hatch,Kurt Horst,Kevin Roberts,Mina Sandusky,Janice Weidman,Hamilton O. Smith,J. Craig Venter +32 more
TL;DR: Comparison of the T. pallidum genome sequence with that of another pathogenic spirochete, Borrelia burgdorferi, the agent of Lyme disease, identified unique and common genes and substantiates the considerable diversity observed among pathogenicSpirochetes.
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Loss-of-function variant in DNASE1L3 causes a familial form of systemic lupus erythematosus
Sulaiman M. Al-Mayouf,Asma Sunker,Reem Abdwani,Safiya Al Abrawi,Fathiya Al-Murshedi,Nadia Al-Hashmi,Abdullah Al Sonbul,Wafaa Sewairi,Aliya Qari,Eiman Abdallah,Mohammed Al-Owain,Saleh Al Motywee,Hanan Al-Rayes,Mais Hashem,Hanif Khalak,Latifa Al-Jebali,Fowzan S. Alkuraya,Fowzan S. Alkuraya +17 more
TL;DR: A rare autosomal recessive form of SLE is identified, in which autozygome analysis revealed a null mutation in the DNASE1L3 gene, which confirms the critical role of impaired clearance of degraded DNA in SLE pathogenesis.
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Prediction of transcription terminators in bacterial genomes.
TL;DR: An algorithm is described that finds rho-independent transcription terminators in bacterial genomes and evaluates the accuracy of its predictions, which ranges from 89 % to 98 %, with corresponding false positive rates of 2 % and 18 %.
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SnB: crystal structure determination via shake‐and‐bake
TL;DR: The focus of this paper is on the details of the SnB program, including its structure, system requirements, running times and the rationale for coding in a combination of C and Fortran.