Hanna Blees

TL;DR: A cellular and molecular checkpoint for intratumoral cDC1 recruitment is revealed that is targeted by tumor-derived PGE2 for immune evasion and that could be exploited for cancer therapy.

TL;DR: In this paper, the authors show that DNGR-1 is a dedicated XP receptor that signals upon ligand engagement to promote phagosomal rupture, which allows escape of phagosome contents into the cytosol, where they access the endogenous major histocompatibility complex class I antigen processing pathway.

TL;DR: It is found that monocytes showed high transporter associated with antigen processing (TAP)-dependent peptide compartmentalization and that after antigen pulsing, they were not able to efficiently stimulate antigen-specific T lymphocytes, compatible with the model that during monocyte-to-DC differentiation, the subcellular relocation of TAP and the regulation of its activity assure spatiotemporal separation of local antigen uptake and processing by monocytes.

TL;DR: In this article , the authors examined the dynamic interactome of the peptide-loading complex (PLC) during differentiation and maturation of Dendritic cells (DCs) generated from blood-derived monocytes.