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Christian Schölz
Researcher at Ludwig Maximilian University of Munich
Publications - 14
Citations - 2079
Christian Schölz is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Acetylation & Lysine. The author has an hindex of 9, co-authored 13 publications receiving 1653 citations. Previous affiliations of Christian Schölz include University of Copenhagen.
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Journal ArticleDOI
Lysine Succinylation Is a Frequently Occurring Modification in Prokaryotes and Eukaryotes and Extensively Overlaps with Acetylation
Brian T. Weinert,Christian Schölz,Sebastian A. Wagner,Vytautas Iesmantavicius,Dan Su,Jeremy A. Daniel,Chunaram Choudhary +6 more
TL;DR: A systems-wide view of succinylation and its dynamic regulation is provided and its extensive overlap with acetylation is shown, indicating that succinylated levels are globally affected by succinyl-CoA concentration.
Journal ArticleDOI
Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli
Brian T. Weinert,Vytautas Iesmantavicius,Sebastian A. Wagner,Christian Schölz,Bertil Gummesson,Petra Beli,Thomas Nyström,Chunaram Choudhary +7 more
TL;DR: It is found that most acetylation occurred at a low level and accumulated in growth-arrested cells in a manner that depended on the formation of acetyl-phosphate (AcP) through glycolysis, suggesting that AcP may acetylate proteins nonenzymatically in cells.
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Time-Resolved Analysis Reveals Rapid Dynamics and Broad Scope of the CBP/p300 Acetylome
Brian T. Weinert,Takeo Narita,Shankha Satpathy,Balaji Srinivasan,Bogi Karbech Hansen,Christian Schölz,William B. Hamilton,Beth E. Zucconi,Wesley W. Wang,Wenshe R. Liu,Joshua M. Brickman,Kesicki Edward A,Albert Lai,Kenneth D. Bromberg,Philip A. Cole,Chunaram Choudhary +15 more
TL;DR: This work combined quantitative proteomics with CBP/p300-specific catalytic inhibitors, bromodomain inhibitor, and gene knockout to reveal a comprehensive map of regulated acetylation sites and their dynamic turnover rates, revealing a dynamic balance between acetylations and deacetylation.
Journal ArticleDOI
Proteomic Analyses Reveal Divergent Ubiquitylation Site Patterns in Murine Tissues
Sebastian Wagner,Sebastian Wagner,Petra Beli,Brian T. Weinert,Christian Schölz,Christian D. Kelstrup,Clifford Young,Michael L. Nielsen,Jesper V. Olsen,Cord Brakebusch,Chunaram Choudhary +10 more
TL;DR: It is demonstrated that different di-glycine-lysine-specific monoclonal antibodies exhibit sequence preferences, and that their complementary use increases the depth of ubiquitylation site analysis, thereby providing a more unbiased view of protein ubiquitylated.
Journal ArticleDOI
Acetylation dynamics and stoichiometry in Saccharomyces cerevisiae.
Brian T. Weinert,Vytautas Iesmantavicius,Tarek Moustafa,Christian Schölz,Sebastian A. Wagner,Christoph Magnes,Rudolf Zechner,Chunaram Choudhary +7 more
TL;DR: Qualitative mass spectrometry data show that a majority of acetylation occurs at very low levels in exponentially growing yeast and is uniformly affected by exposure to acetyl‐CoA.