H
Hannes M. Findeisen
Researcher at University of Münster
Publications - 36
Citations - 2035
Hannes M. Findeisen is an academic researcher from University of Münster. The author has contributed to research in topics: Inflammation & Telomerase reverse transcriptase. The author has an hindex of 18, co-authored 33 publications receiving 1671 citations. Previous affiliations of Hannes M. Findeisen include University of Kentucky & Baylor College of Medicine.
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Journal ArticleDOI
A new glucagon and GLP-1 co-agonist eliminates obesity in rodents
Jonathan Day,Nickki Ottaway,James Patterson,Vasily M. Gelfanov,David L. Smiley,Jas Gidda,Hannes M. Findeisen,Dennis Bruemmer,Daniel J. Drucker,Nilika Chaudhary,Jenna Holland,Jazzminn Hembree,William Abplanalp,Erin Grant,Jennifer Ruehl,Hilary Wilson,Henriette Kirchner,Sarah Kathleen Haas Lockie,Susanna M. Hofmann,Stephen C. Woods,Rubén Nogueiras,Paul T. Pfluger,Diego Perez-Tilve,Richard D. DiMarchi,Matthias H. Tschöp +24 more
TL;DR: Preclinical studies indicate that when full GLP-1 agonism is augmented with an appropriate degree of glucagon receptor activation, body fat reduction can be substantially enhanced without any overt adverse effects.
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Osteopontin: A novel regulator at the cross roads of inflammation, obesity and diabetes.
TL;DR: Recent findings on the role of osteopontin in metabolic disorders, particularly focusing on diabetes and obesity are summarized.
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GLP-1 Secretion Is Increased by Inflammatory Stimuli in an IL-6–Dependent Manner, Leading to Hyperinsulinemia and Blood Glucose Lowering
Florian Kahles,Christina Meyer,Julia Möllmann,S. Diebold,Hannes M. Findeisen,Corinna Lebherz,Christian Trautwein,Alexander Koch,Frank Tacke,Nikolaus Marx,Michael Lehrke +10 more
TL;DR: GLP-1 provides a novel link between the immune system and the gut with strong relevance for metabolic regulation in context of inflammation, and is described to be increased by a variety of inflammatory stimuli, including endotoxin, interleukin-1β, and IL-6.
Journal ArticleDOI
Epigenetic regulation of vascular smooth muscle cell proliferation and neointima formation by histone deacetylase inhibition.
Hannes M. Findeisen,Florence Gizard,Yue Zhao,Hua Qing,Elizabeth B. Heywood,Karrie L. Jones,Dianne Cohn,Dennis Bruemmer +7 more
TL;DR: Findings identify HDAC as a critical component of a transcriptional cascade regulating SMC proliferation and suggest that HDAC might play a pivotal role in the development of proliferative vascular diseases, including atherosclerosis and in-stent restenosis.
Journal ArticleDOI
Oxidative stress accumulates in adipose tissue during aging and inhibits adipogenesis.
Hannes M. Findeisen,Kevin J. Pearson,Florence Gizard,Yue Zhao,Hua Qing,Karrie L. Jones,Dianne Cohn,Elizabeth B. Heywood,Rafael de Cabo,Dennis Bruemmer +9 more
TL;DR: It is demonstrated that aging in mice results in a loss of fat mass and the accumulation of oxidative stress in adipose tissue, demonstrating a previously unrecognized role of oxidative Stress in the regulation of adipogenesis which may contribute to age-associated adipose tissues dysfunction.