F
Florence Gizard
Researcher at University of Kentucky
Publications - 32
Citations - 1942
Florence Gizard is an academic researcher from University of Kentucky. The author has contributed to research in topics: Inflammation & Cell cycle. The author has an hindex of 22, co-authored 32 publications receiving 1765 citations. Previous affiliations of Florence Gizard include Baylor College of Medicine & Pasteur Institute.
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Journal ArticleDOI
Osteopontin Mediates Obesity-Induced Adipose Tissue Macrophage Infiltration and Insulin Resistance in Mice
Takashi Nomiyama,Diego Perez-Tilve,Daisuke Ogawa,Florence Gizard,Yue Zhao,Elizabeth B. Heywood,Karrie L. Jones,Ryuzo Kawamori,Lisa A. Cassis,Matthias H. Tschöp,Dennis Bruemmer +10 more
TL;DR: It is suggested that osteopontin may play a key role in linking obesity to the development of insulin resistance by promoting inflammation and the accumulation of macrophages in adipose tissue.
Journal ArticleDOI
Peroxisome proliferator-activated receptors in reproductive tissues: from gametogenesis to parturition
TL;DR: The roles of PPARs in different compartments of the reproductive axis (from male and female gametogenesis to parturition), with a focus on PPARgamma, and the possible molecular mechanisms underlying the effect of glitazones on PCOS are discussed.
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PPARα inhibits vascular smooth muscle cell proliferation underlying intimal hyperplasia by inducing the tumor suppressor p16INK4a
Florence Gizard,Carole Amant,Olivier Barbier,Stefano Bellosta,Romain Robillard,Frédéric Percevault,Henry Sevestre,Paul Krimpenfort,Alberto Corsini,Jacques Rochette,Corine Glineur,Jean Charles Fruchart,Gérard Torpier,Bart Staels +13 more
TL;DR: The PPARalpha/p16 pathway may be a potential pharmacological target for the prevention of cardiovascular occlusive complications of atherosclerosis and an unexpected role for p16 in SMC cell-cycle control is identified.
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The NR4A orphan nuclear receptor NOR1 is induced by platelet-derived growth factor and mediates vascular smooth muscle cell proliferation.
Takashi Nomiyama,Takafumi Nakamachi,Florence Gizard,Elizabeth B. Heywood,Karrie L. Jones,Naganari Ohkura,Ryuzo Kawamori,Orla M. Conneely,Dennis Bruemmer +8 more
TL;DR: It is demonstrated that SMC isolated from NOR1-deficient mice exhibit decreased cell proliferation and characterize cyclin D1 and D2 as NOR1 target genes in SMC, and further demonstrate that NOR1 functions as a key transcriptional regulator of SMC proliferation.
Journal ArticleDOI
Epigenetic regulation of vascular smooth muscle cell proliferation and neointima formation by histone deacetylase inhibition.
Hannes M. Findeisen,Florence Gizard,Yue Zhao,Hua Qing,Elizabeth B. Heywood,Karrie L. Jones,Dianne Cohn,Dennis Bruemmer +7 more
TL;DR: Findings identify HDAC as a critical component of a transcriptional cascade regulating SMC proliferation and suggest that HDAC might play a pivotal role in the development of proliferative vascular diseases, including atherosclerosis and in-stent restenosis.