H
Hanoch Senderowitz
Researcher at Bar-Ilan University
Publications - 122
Citations - 2286
Hanoch Senderowitz is an academic researcher from Bar-Ilan University. The author has contributed to research in topics: Cystic fibrosis transmembrane conductance regulator & Anomeric effect. The author has an hindex of 24, co-authored 116 publications receiving 1956 citations. Previous affiliations of Hanoch Senderowitz include Weizmann Institute of Science & Hebrew University of Jerusalem.
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Journal ArticleDOI
The Cystic Fibrosis-causing Mutation ΔF508 Affects Multiple Steps in Cystic Fibrosis Transmembrane Conductance Regulator Biogenesis
Patrick H. Thibodeau,John M. Richardson,Wei Wang,Linda Millen,Jarod Watson,Juan L. Mendoza,Kai Du,Sharon Fischman,Hanoch Senderowitz,Gergely L. Lukacs,Kevin L. Kirk,Philip Thomas +11 more
TL;DR: Results indicate that the isolated NBD1 responds to both the ΔF508 mutation and intradomain suppressors of this mutation, and identification of a novel second site suppressor of the defect within the second transmembrane domain suggests that Δf508 also effects interdomain interactions critical for later steps in the biosynthesis of CFTR.
Journal ArticleDOI
A comparison and chemometric analysis of several molecular mechanics force fields and parameter sets applied to carbohydrates
Serge Pérez,Anne Imberty,Søren Balling Engelsen,Jan Gruza,Karim Mazeau,Jesús Jiménez-Barbero,Ana Poveda,Juan-Félix Espinosa,Bouke P van Eyck,Glenn P. Johnson,Alfred D. French,Marie Louise C.E Kouwijzer,Peter D.J Grootenuis,Anna Bernardi,Laura Raimondi,Hanoch Senderowitz,Viviane Durier,Gérard Vergoten,Kjeld Rasmussen +18 more
TL;DR: In this article, the results derived from a chemometric analysis (principal component analysis, PCA) give a global view of the performances of the force fields and parameter sets for carbohydrates.
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Docking studies on DNA intercalators.
TL;DR: Analysis of ligand binding sites preferences in 63 high resolution DNA-intercalator complexes available in the PDB revealed that AUTODOCK performs best for intercalators characterized by a large number of aromatic rings, low flexibility, high molecular weight, and a small number of hydrogen bond acceptors.
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A Smart Monte Carlo Technique for Free Energy Simulations of Multiconformational Molecules. Direct Calculations of the Conformational Populations of Organic Molecules
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Small molecule correctors of F508del-CFTR discovered by structure-based virtual screening
Ori Kalid,Martin Mense,Sharon Fischman,Alina Shitrit,Hermann Bihler,Efrat Ben-Zeev,Nili Schutz,Nicoletta Pedemonte,Philip Thomas,Robert J. Bridges,Diana R. Wetmore,Diana R. Wetmore,Yael Marantz,Hanoch Senderowitz +13 more
TL;DR: It is hypothesized that compounds binding at inter-domain interfaces may improve the stability of the protein, potentially affecting the folding yield or surface stability, and may prove to be better leads for the development of CF therapeutics than either pure correctors or pure potentiators.