T
Thomas Jostock
Researcher at University of Mainz
Publications - 8
Citations - 1799
Thomas Jostock is an academic researcher from University of Mainz. The author has contributed to research in topics: Glycoprotein 130 & Signal transduction. The author has an hindex of 7, co-authored 8 publications receiving 1714 citations. Previous affiliations of Thomas Jostock include University of Kiel.
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Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo.
Raja Atreya,Jonas Mudter,Susetta Finotto,Jürgen Müllberg,Thomas Jostock,Stefan Wirtz,M Schütz,Brigitte Bartsch,Martin H. Holtmann,Christoph Becker,Dennis Strand,J Czaja,Joerg F. Schlaak,Hans-Anton Lehr,Frank Autschbach,G. Schürmann,N Nishimoto,Kazuyuki Yoshizaki,Hiroshi Ito,Tadamitsu Kishimoto,Peter R. Galle,Stefan Rose-John,Markus F. Neurath +22 more
TL;DR: Assessment of the contribution of the pro-inflammatory cytokine interleukin (IL)-6 to the increased resistance of mucosal T cells against apoptosis in Crohn disease indicates that a pathway of T-cell activation driven by IL-6–sIL-6R contributes to the perpetuation of chronic intestinal inflammation.
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Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice
Athena Chalaris,Nina Adam,Christian Sina,Philip Rosenstiel,Judith Lehmann-Koch,Peter Schirmacher,Dieter Hartmann,Joanna Cichy,Olga Gavrilova,Stefan Schreiber,Thomas Jostock,Vance Matthews,Robert Häsler,Christoph Becker,Markus F. Neurath,Karina Reiß,Paul Saftig,Jürgen Scheller,Stefan Rose-John +18 more
TL;DR: It is demonstrated that ADAM17 is needed for vital regenerative activities during the immune response by regulating the systemic availability of the proinflammatory cytokine TNF and in defective regeneration of epithelial cells and breakdown of the intestinal barrier.
Journal Article
The importance of shedding of membrane proteins for cytokine biology.
TL;DR: The current knowledge of shedding enzymes, the ADAM protein family, the mechanism of shedding as well as physiological consequences of shedding of cytokines and cytokine receptors for cytokine biology are described.
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Human herpes virus 8 interleukin-6 homologue triggers gp130 on neuronal and hematopoietic cells.
Susanne H. Hoischen,Petra Vollmer,Pia März,Suat Özbek,Katharina Götze,Christian Peschel,Thomas Jostock,Till Geib,Jürgen Müllberg,Sabine Mechtersheimer,Martina Fischer,Joachim Grötzinger,Peter R. Galle,Stefan Rose-John,Stefan Rose-John +14 more
TL;DR: Human herpes virus-8 (HHV8) encodes a cytokine named viral interleukin-6 (vIL-6) that shares 25% amino-acid identity with its human homologue, and vIL- 6 was shown to induce neuronal differentiation of rat pheochromocytoma cells and to stimulate colony formation of human hematopoietic progenitor cells.
Journal ArticleDOI
The membrane proximal cytokine receptor domain of the human interleukin-6 receptor is sufficient for ligand binding but not for gp130 association.
Suat Özbek,Joachim Grötzinger,Barbara Krebs,Martina Fischer,Axel Wollmer,Thomas Jostock,Jürgen Müllberg,Stefan Rose-John +7 more
TL;DR: The data demonstrate the ligand binding function of the third domain and point to an important role of the second domain in complex formation with gp130 and signaling.