J
Jürgen Müllberg
Researcher at University of Mainz
Publications - 39
Citations - 6482
Jürgen Müllberg is an academic researcher from University of Mainz. The author has contributed to research in topics: Glycoprotein 130 & Receptor. The author has an hindex of 30, co-authored 39 publications receiving 6236 citations. Previous affiliations of Jürgen Müllberg include RWTH Aachen University.
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Journal ArticleDOI
ULBPs, Novel MHC Class I–Related Molecules, Bind to CMV Glycoprotein UL16 and Stimulate NK Cytotoxicity through the NKG2D Receptor
David Cosman,Jürgen Müllberg,Claire L. Sutherland,Wilson Chin,Richard J. Armitage,William C. Fanslow,Marek Kubin,N. Jan Chalupny +7 more
TL;DR: Masking of NK cell recognition of ULBP or MIC antigens by UL16 provides a potential mechanism by which human cytomegalovirus-infected cells might evade attack by the immune system.
Journal ArticleDOI
Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo.
Raja Atreya,Jonas Mudter,Susetta Finotto,Jürgen Müllberg,Thomas Jostock,Stefan Wirtz,M Schütz,Brigitte Bartsch,Martin H. Holtmann,Christoph Becker,Dennis Strand,J Czaja,Joerg F. Schlaak,Hans-Anton Lehr,Frank Autschbach,G. Schürmann,N Nishimoto,Kazuyuki Yoshizaki,Hiroshi Ito,Tadamitsu Kishimoto,Peter R. Galle,Stefan Rose-John,Markus F. Neurath +22 more
TL;DR: Assessment of the contribution of the pro-inflammatory cytokine interleukin (IL)-6 to the increased resistance of mucosal T cells against apoptosis in Crohn disease indicates that a pathway of T-cell activation driven by IL-6–sIL-6R contributes to the perpetuation of chronic intestinal inflammation.
Journal ArticleDOI
Soluble gp130 is the natural inhibitor of soluble interleukin‐6 receptor transsignaling responses
Thomas Jostock,Jürgen Müllberg,Suat Özbek,Raja Atreya,Guido Blinn,Nicole Voltz,Martina Fischer,Markus F. Neurath,Stefan Rose-John +8 more
TL;DR: Recombinant sgp130 protein could be used to block the anti-apoptotic effect of sIL-6R on lamina propria cells from Crohn disease patients and is expected to be a valuable therapeutic tool to specifically block disease states in which sIL -6R transsignaling responses exist, e.g. in morbusCrohn disease.
Journal ArticleDOI
The soluble interleukin‐6 receptor is generated by shedding
Jürgen Müllberg,Heidi Schooltink,T. Stoyan,Günther M,Lutz Graeve,Buse G,Andrzej Mackiewicz,Peter C. Heinrich,Stefan Rose-John +8 more
TL;DR: The ligand‐binding subunit (gp80) of the human interleukin‐6 receptor (IL‐6R) was transiently expressed in COS‐7 cells and the metabolically labeled protein was shown to be quantitatively released from the membrane within 20 h.
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The function of the soluble interleukin 6 (IL-6) receptor in vivo: sensitization of human soluble IL-6 receptor transgenic mice towards IL-6 and prolongation of the plasma half-life of IL-6.
Malte Peters,S Jacobs,Marc Ehlers,Petra Vollmer,Jürgen Müllberg,Eckhard Wolf,Gottfried Brem,K H Meyer zum Büschenfelde,Stefan Rose-John +8 more
TL;DR: It is reported here that in the presence of hsIL-6R, mice are hypersensitized towards hIL- 6, mounting an acute phase protein gene induction at significantly lower IL-6 dosages compared to control animals, and the detected acute phase response persists for a longer period of time.