Brigitte Bartsch

TL;DR: Assessment of the contribution of the pro-inflammatory cytokine interleukin (IL)-6 to the increased resistance of mucosal T cells against apoptosis in Crohn disease indicates that a pathway of T-cell activation driven by IL-6–sIL-6R contributes to the perpetuation of chronic intestinal inflammation.

TL;DR: It is suggested that 6-Thio-GTP derivates may be useful as potent immunosuppressive agents in autoimmune diseases and organ transplantation and in the control of T cell apoptosis by modulation of Rac1 activation upon CD28 costimulation.

TL;DR: A critical role is indicated for GATA-3 in the effector phase of a murine asthma model and local delivery of GATA -3 antisense oligonucleotides may be a novel approach for the treatment of airway hyperresponsiveness such as in asthma.

TL;DR: The analysis of STAT activation patterns could serve as a helpful tool to characterize intestinal inflammation and the IL-6/ STAT-3 rather than the IFN-γ/STAT-1 signaling pathway emerges as a key target for the development of future therapeutic concepts in IBD.

TL;DR: Clinically effective anti-TNF antibodies are able to induce T-cell apoptosis in IBD only when mucosal TNFR2(+) T cells are cocultured with mTNF-expressing CD14(+) macrophages.