H
Hans Christian Spangenberg
Researcher at University of Freiburg
Publications - 52
Citations - 2008
Hans Christian Spangenberg is an academic researcher from University of Freiburg. The author has contributed to research in topics: Hepatocellular carcinoma & Hepatitis C. The author has an hindex of 17, co-authored 52 publications receiving 1916 citations. Previous affiliations of Hans Christian Spangenberg include University Medical Center Freiburg.
Papers
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Journal ArticleDOI
Viral and immunological determinants of hepatitis C virus clearance, persistence, and disease
Robert Thimme,Jens Bukh,Hans Christian Spangenberg,Stefan Wieland,Janell Pemberton,Carola Steiger,Sugantha Govindarajan,Robert H. Purcell,Francis V. Chisari +8 more
TL;DR: The results indicate that HCV spread outpaces the T cell response and thatHCV rapidly induces but is not controlled by IFN-α/β; that viral clearance follows the entry and accumulation of HCV-specific IFN -γ-producing T cells in the liver; and that it may not require the destruction of infected cells.
Journal ArticleDOI
Dominant influence of an HLA‐B27 restricted CD8+ T cell response in mediating HCV clearance and evolution
Christoph Neumann-Haefelin,Susan McKiernan,Scott M. Ward,Sergei Viazov,Hans Christian Spangenberg,Thomas Killinger,Thomas F. Baumert,N Nazarova,Isabelle Sheridan,Oliver G. Pybus,Fritz von Weizsäcker,Michael Roggendorf,Dermot Kelleher,Paul Klenerman,Hubert E. Blum,Robert Thimme +15 more
TL;DR: The results suggest a dominant role of HLA‐B27 in mediating spontaneous viral clearance as well as viral evolution in HCV infection and mechanistically link both associations to a dominant novel CD8+ T cell epitope.
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Expansion and contraction of the hepatitis B virus transcriptional template in infected chimpanzees
Stefan Wieland,Hans Christian Spangenberg,Robert Thimme,Robert H. Purcell,Francis V. Chisari +4 more
TL;DR: Surprisingly, despite this multipronged response, traces of cccDNA persist indefinitely in the liver, likely providing a continuous antigenic stimulus that confers lifelong immunity.
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Perioperative Mortality After Non-hepatic General Surgery in Patients with Liver Cirrhosis: an Analysis of 138 Operations in the 2000s Using Child and MELD Scores
TL;DR: The authors' results demonstrate that perioperative mortality remains high in patients with liver cirrhosis undergoing general surgery, especially in emergent situations, and that patients with poor liver function and/or need for blood transfusions even had a very high mortality.
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Serum markers of hepatocellular carcinoma.
TL;DR: Screening strategies including alpha-fetoprotein (AFP) and ultrasound every 6 months in patients with liver cirrhosis, the major risk factor for HCC development, have been recommended to detect HCC at earlier stages amenable to effective treatment strategies.