Janell Pemberton

TL;DR: The results indicate that HCV spread outpaces the T cell response and thatHCV rapidly induces but is not controlled by IFN-α/β; that viral clearance follows the entry and accumulation of HCV-specific IFN -γ-producing T cells in the liver; and that it may not require the destruction of infected cells.

TL;DR: The results show that a vigorous and multispecific CD4+ proliferative T‐cell response is maintained indefinitely after recovery from HCV infection whereas it is weak and focused in persistently infected patients.

TL;DR: Inhibition of the TIR domain-mediated MyD88/IL1-RI interaction by a low molecular weight, cell-penetrating TIRdomain mimic suggests an intracellular site for antiinflammatory drug action.

TL;DR: The data suggest that UCP2 may represent a drug target for slowing the progression of Parkinson's disease, and transgenic mice overexpressing UCP1 in catecholaminergic neurons showed neuroprotection and retention of locomotor functions.

TL;DR: The results demonstrate the concept of degenerate immunogenicity across HLA class supertype boundaries in a human viral disease setting and could facilitate the development of an epitope-based therapeutic vaccine to terminate chronic HBV infection that could provide a broad and diverse population coverage with a single peptide.