H
Hans J. Tanke
Researcher at Leiden University
Publications - 56
Citations - 4377
Hans J. Tanke is an academic researcher from Leiden University. The author has contributed to research in topics: Fluorescence loss in photobleaching & Gene mapping. The author has an hindex of 29, co-authored 56 publications receiving 4238 citations. Previous affiliations of Hans J. Tanke include Erasmus University Rotterdam.
Papers
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Journal ArticleDOI
High-resolution DNA Fiber-FISH for genomic DNA mapping and colour bar-coding of large genes
Ralph J. Florijn,L A Bonden,Hans Vrolijk,Joop Wiegant,J.-W. Vaandrager,Frank Baas,J.T. den Dunnen,Hans J. Tanke,G.J.B. van Ommen,A. K. Raap +9 more
TL;DR: Two-colour Fiber-FISH mapping showed to be capable for accurately sizing gaps and overlaps, and to identify chimeric or repeat sequence containing cosmids across a 400 kb region at once, and was used to map two DMD deletion breakpoints in patient DNA with an accuracy of 1-2 kb.
Journal Article
Comparative Genomic Hybridization of Cancer of the Gastroesophageal Junction: Deletion of 14Q31–32.1 Discriminates between Esophageal (Barrett’s) and Gastric Cardia Adenocarcinomas
Herman van Dekken,Eric Geelen,Winand N.M. Dinjens,Bas P. L. Wijnhoven,Hugo W. Tilanus,Hans J. Tanke,Carla Rosenberg +6 more
TL;DR: A detailed comparative genomic hybridization-map of GEJ adenocarcinomas documenting new genetic changes, as well as candidate genes involved was provided, and genetic divergence was revealed in this poorly understood group of cancers.
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FISH and chips: automation of fluorescent dot counting in interphase cell nuclei.
TL;DR: A completely automated fluorescence microscope system that can examine 500 cells in approximately 15 min to determine the number of labeled chromosomes in each cell nucleus, and its accuracies are comparable to panels of human experts (manual).
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Detection of chromosome aberrations in interphase tumor nuclei by nonradioactive in situ hybridization.
Petra M. Nederlof,Silvia van der Flier,Anton K. Raap,Hans J. Tanke,Mels van der Ploeg,Frank H.A.C. Kornips,Joep P.M. Geraedts +6 more
TL;DR: In a blind study, chromosome aberrations in tumor cells were analyzed by conventional cytogenetic techniques (G banding) and nonradioactive in situ hybridization with chromosome-specific probes and gave reliable results and allowed detection of cell subpopulations that were not detected by analyzing metaphase chromosomes.
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New insights in the cellular processing of platinum antitumor compounds, using fluorophore-labeled platinum complexes and digital fluorescence microscopy.
TL;DR: Cisplatin-derived complexes with fluorescent tags afford a new insight into the cellular processing of these complexes and therefore may contribute to further unraveling of the mechanism of platinum antitumor complexes.