H
Hans Røigaard
Researcher at Aarhus University
Publications - 8
Citations - 856
Hans Røigaard is an academic researcher from Aarhus University. The author has contributed to research in topics: Receptor & Endocytosis. The author has an hindex of 7, co-authored 8 publications receiving 826 citations.
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Journal ArticleDOI
Molecular identification of a novel candidate sorting receptor purified from human brain by receptor-associated protein affinity chromatography
Claus Munck Petersen,Morten Nielsen,Anders Nykjaer,Linda Jacobsen,Niels Tommerup,Hanne H. Rasmussen,Hans Røigaard,Jørgen Gliemann,Peder Madsen,Søren K. Moestrup +9 more
TL;DR: Exercise of a chimeric receptor containing the cytoplasmic tail of gp95/sortilin demonstrates evidence that the tail conveys colocalization with the cation-independent mannose6-phosphate receptor in endosomes and the Golgi compartment.
Journal ArticleDOI
Epithelial glycoprotein-330 mediates endocytosis of plasminogen activator-plasminogen activator inhibitor type-1 complexes.
Søren K. Moestrup,Søren Nielsen,Peter A. Andreasen,K E Jørgensen,Anders Nykjaer,Hans Røigaard,Jørgen Gliemann,E. I. Christensen +7 more
TL;DR: The results establish an endocytotic function of gp330 and suggest that gp330 is an important component of the fibrinolytic system in gp330-containing epithelial as found in, for example, kidney and lung.
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Mannose 6-Phosphate/Insulin-like Growth Factor–II Receptor Targets the Urokinase Receptor to Lysosomes via a Novel Binding Interaction
Anders Nykjaer,Erik Ilsø Christensen,Henrik Vorum,Henrik Hager,Claus Munck Petersen,Hans Røigaard,Hye Y. Min,Frederik Vilhardt,Lisbeth Birk Møller,Stuart Kornfeld,Jørgen Gliemann +10 more
TL;DR: It is concluded that a site within CIMPR, distinct from its previously known ligand binding sites, binds uPAR and modulates its subcellular distribution.
Journal ArticleDOI
A carboxyl-terminal fragment of lipoprotein lipase binds to the low density lipoprotein receptor-related protein and inhibits lipase-mediated uptake of lipoprotein in cells.
Anders Nykjaer,Morten Nielsen,Aivar Lookene,N Meyer,Hans Røigaard,Michael Etzerodt,U Beisiegel,G. Olivecrona,Jørgen Gliemann +8 more
TL;DR: The fragment contains the site for binding to LRP and a candidate site for interaction with heparan sulfate proteoglycans, whereas binding to lipoproteins is inefficient, and can inhibit the lipase-mediated lipoprotein uptake.