H
Hanyin Cheng
Researcher at Thomas Jefferson University
Publications - 21
Citations - 1446
Hanyin Cheng is an academic researcher from Thomas Jefferson University. The author has contributed to research in topics: Melanoma & Exome sequencing. The author has an hindex of 13, co-authored 20 publications receiving 1225 citations. Previous affiliations of Hanyin Cheng include University of Texas at El Paso & University of Texas MD Anderson Cancer Center.
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Journal ArticleDOI
Circulating Plasma MiR-141 Is a Novel Biomarker for Metastatic Colon Cancer and Predicts Poor Prognosis
Hanyin Cheng,Lina Zhang,David Cogdell,Hong Zheng,Aaron J. Schetter,Matti Nykter,Curtis C. Harris,Kexin Chen,Stanley R. Hamilton,Wei Zhang +9 more
TL;DR: It is proposed that plasma miR-141 may represent a novel biomarker that complements CEA in detecting colon cancer with distant metastasis and that high levels of miR -141 in plasma were associated with poor prognosis.
Journal ArticleDOI
Integrated analyses identify a master microRNA regulatory network for the mesenchymal subtype in serous ovarian cancer
Da Yang,Yan Sun,Yan Sun,Limei Hu,Hong Zheng,Hong Zheng,Ping Ji,Chad V. Pecot,Yanrui Zhao,Sheila Reynolds,Hanyin Cheng,Rajesha Rupaimoole,David Cogdell,Matti Nykter,Russell Broaddus,Cristian Rodriguez-Aguayo,Gabriel Lopez-Berestein,Jinsong Liu,Ilya Shmulevich,Anil K. Sood,Kexin Chen,Wei Zhang +21 more
TL;DR: Integrated genomic analyses revealed a miRNA-regulatory network that further defined a robust integrated mesenchymal subtype associated with poor overall survival in serous ovarian cancer (OvCa) and predicted eight key miRNAs were predicted to regulate 89% of the targets in this network.
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Reanalysis of Clinical Exome Sequencing Data
Pengfei Liu,Linyan Meng,Elizabeth A. Normand,Fan Xia,Xiaofei Song,Andrew R. Ghazi,Jill A. Rosenfeld,Pilar L. Magoulas,Alicia Braxton,Patricia A. Ward,Hongzheng Dai,Bo Yuan,Weimin Bi,Rui Xiao,Xia Wang,Theodore Chiang,Francesco Vetrini,Weimin He,Hanyin Cheng,Jie Dong,Charul Gijavanekar,Paul J. Benke,Jonathan A. Bernstein,Tanya N. Eble,Yasemen Eroglu,Deanna J. Erwin,Luis F. Escobar,James B. Gibson,Karen W. Gripp,Soledad Kleppe,Mary Kay Koenig,Andrea M. Lewis,Marvin R. Natowicz,Pedro Mancias,La Keesha Minor,Fernando Scaglia,Christian P. Schaaf,Haley Streff,Hilary J. Vernon,Crescenda L. Uhles,Elaine H. Zackai,Nan Wu,V. Reid Sutton,Arthur L. Beaudet,Donna M. Muzny,Richard A. Gibbs,Jennifer E. Posey,Seema R. Lalani,Chad A. Shaw,Christine M. Eng,James R. Lupski,Yaping Yang +51 more
TL;DR: Reanalysis of Clinical Exome Data and Diagnostic Yield As knowledge about genetic causes of disease improves, periodic reanalysis of clinical exome sequence could yield new genetic information.
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The next generation of population-based spinal muscular atrophy carrier screening: comprehensive pan-ethnic SMN1 copy-number and sequence variant analysis by massively parallel sequencing.
Yanming Feng,Xiaoyan Ge,Linyan Meng,Jennifer Scull,Jianli Li,Xia Tian,Tao Zhang,Weihong Jin,Hanyin Cheng,Xia Wang,Mari Tokita,Pengfei Liu,Hui Mei,Yue Wang,Fangyuan Li,Eric S. Schmitt,Wei V. Zhang,Wei V. Zhang,Donna M. Muzny,Shu Wen,Zhao Chen,Yaping Yang,Arthur L. Beaudet,Xiaoming Liu,Christine M. Eng,Christine M. Eng,Fan Xia,Lee-Jun C. Wong,Jinglan Zhang +28 more
TL;DR: A novel, comprehensive SMN1 copy-number and sequence variant analysis method by NGS is developed that demonstrated improved SMA carrier detection rates across the entire population examined.
Journal ArticleDOI
Paracrine Effect of NRG1 and HGF Drives Resistance to MEK Inhibitors in Metastatic Uveal Melanoma
TL;DR: Preclinical evidence for the use of MEK inhibitors in combination with clinical-grade anti-ERBB3 or anti-cMET monoclonal antibodies in metastatic uveal melanoma patients is provided.