Hao Ding

TL;DR: In this article, the authors found that conventionalization of adult germ-free C57BL/6 mice with a normal microbiota harvested from the distal intestine (cecum) of conventionally raised animals produces a 60% increase in body fat content and insulin resistance within 14 days despite reduced food intake.

TL;DR: Crosses of Rtel(+/-) mice with Mus spretus showed that Rtel from the Mus musculus parent is required for telomere elongation of M. spretUS chromosomes in F1 cells, concluding that R tel is an essential gene that regulates telomeres length and prevents genetic instability.

TL;DR: A transgenic mouse astrocytoma model developed using the glial fibrillary acidic protein (GFAP) promoter to express oncogenic V(12)Ha-ras, specifically inAstrocytes recapitulates many of the molecular histopathological and growth characteristics of human malignant astroCytomas in a reproducible, germ-line-transmitted, and high-penetrance manner.

TL;DR: It is shown that Pdgfc−/− mice die in the perinatal period owing to feeding and respiratory difficulties associated with a complete cleft of the secondary palate, and that PDGF-C signaling is a new pathway in palatogenesis, different from, and independent of, those previously implicated.

TL;DR: It is demonstrated that astrocyte-specific expression of EGFRvIII alone is insufficient for gliomagenesis but rather contributes to glioma progression in the context of existing predisposing genetic changes.