H
Hans Boström
Researcher at University of Gothenburg
Publications - 7
Citations - 2425
Hans Boström is an academic researcher from University of Gothenburg. The author has contributed to research in topics: Platelet-derived growth factor receptor & Platelet-derived growth factor. The author has an hindex of 7, co-authored 7 publications receiving 2329 citations. Previous affiliations of Hans Boström include University College London.
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Journal ArticleDOI
PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis
Hans Boström,Karen Willetts,Karen Willetts,Milos Pekny,Per Levéen,Per Lindahl,Håkan Hedstrand,Marcela Pekna,Mats Hellström,Samuel Gebre-Medhin,Martin Schalling,Mia Nilsson,Siri Kurland,Jan Törnell,John K. Heath,Christer Betsholtz +15 more
TL;DR: The two PDGF null phenotypes reveal analogous morphogenetic functions for myofibroblast-type cells in lung and kidney organogenesis, and show that PDGF-B is required in the ontogeny of kidney mesangial cells.
Journal ArticleDOI
PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor.
Xuri Li,Annica Pontén,Karin Aase,L. Karlsson,Alexandra Abramsson,Marko Uutela,Gudrun Bäckström,Mats Hellström,Hans Boström,Hong Li,Philippe Soriano,Christer Betsholtz,Carl-Henrik Heldin,Kari Alitalo,Arne Östman,Ulf Eriksson +15 more
TL;DR: A new PDGF, PDGF-C, is identified, which binds to and activates the PDGF α-receptor and is activated by proteolysis and induces proliferation of fibroblasts when overexpressed in transgenic mice.
Journal ArticleDOI
Defective oligodendrocyte development and severe hypomyelination in PDGF-A knockout mice
Marcus Fruttiger,L. Karlsson,Anita C. Hall,Alexandra Abramsson,Andrew R. Calver,Hans Boström,Karen Willetts,Claes Henric Bertold,John K. Heath,Christer Betsholtz,William D. Richardson +10 more
TL;DR: Evidence is provided that myelin proteolipid protein (PLP/DM-20)-positive cells in the late embryonic brainstem are non-dividing cells, presumably immature oligodendrocytes, and not proliferating precursors.
Journal ArticleDOI
A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling.
Hao Ding,Xiaoli Wu,Hans Boström,Injune Kim,Nicole Wong,Bonny Tsoi,Meredith P. O'Rourke,Gou Young Koh,Philippe Soriano,Christer Betsholtz,Thomas C. Hart,Mary L. Marazita,L. Leigh Field,Patrick P.L. Tam,Andras Nagy,Andras Nagy +15 more
TL;DR: It is shown that Pdgfc−/− mice die in the perinatal period owing to feeding and respiratory difficulties associated with a complete cleft of the secondary palate, and that PDGF-C signaling is a new pathway in palatogenesis, different from, and independent of, those previously implicated.
Journal ArticleDOI
PDGF-A/PDGF alpha-receptor signaling is required for lung growth and the formation of alveoli but not for early lung branching morphogenesis.
TL;DR: Lung development in pdgfrα −/− embryos and lung primordia grown in vitro is analyzed and it is concluded that, although PDGF‐AA signaling over PDGFRα may have direct or indirect roles in overall lung growth, it does not specifically control early branching of the lung epithelium.