Hao-Li Liu

TL;DR: Synergistic targeting and image monitoring are powerful techniques for the delivery of macromolecular chemotherapeutic agents into the CNS under the guidance of MRI and significantly increased the deposition of therapeutic MNPs in brains with intact or compromised blood–brain barriers.

TL;DR: Focused ultrasound significantly enhanced the penetration of BCNU through the blood-brain barrier in normal and tumor-implanted brains without causing hemorrhaging, demonstrating a means of increasing localized chemotherapeutic drug delivery for brain tumor treatment and strongly supports the feasibility of this treatment in a clinical setting.

TL;DR: A thermoresponsive bubble-generating liposomal system is proposed for triggering localized extracellular drug delivery and may also provide an ability to monitor a temperature-controlled drug delivery process.

TL;DR: This study provides a new approach for designing multifunctional MBs to facilitate FUS-mediated chemotherapy for brain tumor treatment and in tumor-bearing animals, BCNU-MBs with FUS controlled tumor progression and improved median survival.

TL;DR: Current preclinical studies which demonstrate the reports by using FUS with MB-facilitated drug delivery technology in brain tumor treatment and newly developed multifunctional theranostic MBs for FUS-induced BBB opening for brain tumor therapy are reviewed.