Hao Pei

TL;DR: Functional, multivalent DNA nanostructures are developed by appending unmethylated CpG motifs to three-dimensional DNA tetrahedra that are compact, mechanically stable, and noncytotoxic and expected to become a promising tool for targeted drug delivery.

TL;DR: This work devise a new concept to achieve improved probe–target recognition properties by introducing a probe bearing a 3D DNA nanostructure-based chip platform and provides a significantly enhanced spatial positioning range and accessibility of the probes on a surface over previously reported linear or stem-loop probe structures.

TL;DR: An ultrasensitive detection platform for microRNA is demonstrated by combining the tetrahedral DNA nanostructure probes and hybridization chain reaction (HCR) amplification and the uncontrolled surface immobilization and consumption of target molecules that limit the amplification efficiency of supersandwich are eliminated.

TL;DR: A novel strategy for spatially controlled functionalization of AuNPs with designed diblock oligonucleotides that are free of modifications is reported, which results in DNA-AuNPs nanoconjugates with high and tunable hybridization ability, which form the basis of a rapid plasmonic DNA sensor.

TL;DR: Recent advances on using various DNA nanostructures, e.g., DNA nanotubes, DNA tetrahedra, and DNA origami nanorobot, as drug delivery nanocarriers are reviewed, and several examples aiming at therapeutic applications with CpG‐based immunostimulatory and siRNA‐based gene silencing oligonucleotides are demonstrated.