H
Hao Sun
Researcher at Guangzhou Institutes of Biomedicine and Health
Publications - 9
Citations - 396
Hao Sun is an academic researcher from Guangzhou Institutes of Biomedicine and Health. The author has contributed to research in topics: Reprogramming & Basic fibroblast growth factor. The author has an hindex of 7, co-authored 9 publications receiving 281 citations. Previous affiliations of Hao Sun include Chinese Academy of Sciences & University of Minnesota.
Papers
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Journal ArticleDOI
Sequential introduction of reprogramming factors reveals a time-sensitive requirement for individual factors and a sequential EMT-MET mechanism for optimal reprogramming.
Xiaopeng Liu,Hao Sun,Hao Sun,Jing Qi,Linli Wang,Songwei He,Jing Liu,Chengqian Feng,Chunlan Chen,Wen Li,Yunqian Guo,Dajiang Qin,Guangjin Pan,Jiekai Chen,Duanqing Pei,Hui Zheng +15 more
TL;DR: It is reported that a sequential introduction protocol (Oct4–Klf4 first, then c-Myc and finally Sox2) outperforms the simultaneous one and reveals a time-sensitive role of individual factors for optimal reprogramming and a sequential EMT–MET mechanism at the start of reprograming.
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The SARS-CoV-2 protein ORF3a inhibits fusion of autophagosomes with lysosomes
TL;DR: In this article, the authors systematically screened 28 viral proteins of SARS-CoV-2 and identified that ORF3a strongly inhibited autophagic flux by blocking the fusion of autophagosomes with lysosomes.
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Meta-Analysis of EMT Datasets Reveals Different Types of EMT.
TL;DR: The existence of different types of EMT was the possible reason for its complex role in multiple biological processes as well as the grouping of 74 human EMT-induction samples into five distinct clusters, and the identification of distinct pathways in these different clusters.
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Lysine-specific histone demethylase 1 inhibition promotes reprogramming by facilitating the expression of exogenous transcriptional factors and metabolic switch
Hao Sun,Lining Liang,Yuan Li,Chengqian Feng,Lingyu Li,Yixin Zhang,Songwei He,Duanqing Pei,Yunqian Guo,Hui Zheng +9 more
TL;DR: LSD1 inhibition promotes reprogramming by facilitating the expression of exogenous transcriptional factors and metabolic switch and promoted the conversion from pre-iPSCs to iPSCs by facilitated the similar metabolic switch.
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Reprogramming somatic cells to cells with neuronal characteristics by defined medium both in vitro and in vivo
Songwei He,Yiping Guo,Yixin Zhang,Yuan Li,Chengqian Feng,Xiang Li,Lilong Lin,Lin Guo,Haitao Wang,Chunhua Liu,Yi Zheng,Chuanming Luo,Qiang Liu,Fuhui Wang,Hao Sun,Lining Liang,Lingyu Li,Lingyu Li,Huanxing Su,Jiekai Chen,Duanqing Pei,Hui Zheng +21 more
TL;DR: This 5C medium not only provides a means to derive cells with neuronal characteristics without viral transfection in vitro but might also be useful to produce neurons in vivo for neurodegenerative disease treatment.