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Yong Lin
Researcher at Laboratory of Molecular Biology
Publications - 18
Citations - 548
Yong Lin is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Hepatitis B virus & Virus. The author has an hindex of 9, co-authored 18 publications receiving 293 citations. Previous affiliations of Yong Lin include Huazhong University of Science and Technology.
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The SARS-CoV-2 protein ORF3a inhibits fusion of autophagosomes with lysosomes
TL;DR: In this article, the authors systematically screened 28 viral proteins of SARS-CoV-2 and identified that ORF3a strongly inhibited autophagic flux by blocking the fusion of autophagosomes with lysosomes.
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O-GlcNAc transferase promotes influenza A virus-induced cytokine storm by targeting interferon regulatory factor-5.
Qiming Wang,Peining Fang,Rui He,Mengqi Li,Haisheng Yu,Li Zhou,Yu Yi,Fubing Wang,Yuan Rong,Zhang Yi,Aidong Chen,Nanfang Peng,Yong Lin,Mengji Lu,Ying Zhu,Guoping Peng,Li-qun Rao,Shi Liu +17 more
TL;DR: A molecular mechanism by which HBP-mediated O-GlcNAcylation regulates IRF5 function during IAV infection is identified, highlighting the importance of glucose metabolism in IAV-induced cytokine storm.
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Poly(I:C) Treatment Leads to Interferon-Dependent Clearance of Hepatitis B Virus in a Hydrodynamic Injection Mouse Model
Jun Wu,Shunmei Huang,Xiaoli Zhao,Mingfa Chen,Yong Lin,You-chen Xia,Chan Sun,Xuecheng Yang,Junzhong Wang,Yan Guo,Jingjiao Song,Ejuan Zhang,Baoju Wang,Xin Zheng,Joerg F. Schlaak,Mengji Lu,Dongliang Yang +16 more
TL;DR: It is demonstrated that hepatic TLR3 activation led to clearance of hepatitis B virus in an HBV mouse model, implicating the potential of intrahepatic Toll-like receptor 3 (TLR3) activation for the treatment of chronic hepatitis B patients.
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Hepatitis B virus rigs the cellular metabolome to avoid innate immune recognition
Li Zhou,Rui He,Peining Fang,Mengqi Li,Haisheng Yu,Qiming Wang,Yi Yu,Fubing Wang,Zhang Yi,Aidong Chen,Nanfang Peng,Yong Lin,Zhang Rui,Mirko Trilling,Ruth Broering,Mengji Lu,Ying Zhu,Shi Liu +17 more
TL;DR: In this paper, the authors demonstrate that HBV sequesters MAVS from RIG-I by forming a ternary complex including hexokinase (HK) and showed that HK2 and glycolysis-derived lactate have important functions in the immune escape of HBV and that energy metabolism regulates innate immunity during HBV infection.