H
Haoxing Zhang
Researcher at Mayo Clinic
Publications - 27
Citations - 1162
Haoxing Zhang is an academic researcher from Mayo Clinic. The author has contributed to research in topics: DNA damage & DNA repair. The author has an hindex of 16, co-authored 25 publications receiving 913 citations. Previous affiliations of Haoxing Zhang include Shenzhen University & Fudan University.
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Journal ArticleDOI
Sumoylation of MDC1 is important for proper DNA damage response.
TL;DR: MDC1 is sumoylated following DNA damage, and the sumoylation of MDC1 at Lys1840 is required for MDC 1 degradation and removal of M DC1 and 53BP1 from sites of DNA damage.
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CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1
Tongzheng Liu,Jia Yu,Min Deng,Yujiao Yin,Haoxing Zhang,Kuntian Luo,Kuntian Luo,Bo Qin,Yunhui Li,Chenming Wu,Tao Ren,Yang Han,Peng Yin,Jung Jin Kim,Seung Baek Lee,Jing Lin,Lizhi Zhang,Jun Zhang,Somaira Nowsheen,Liewei Wang,Judy C. Boughey,Matthew P. Goetz,Jian Yuan,Jian Yuan,Zhenkun Lou +24 more
TL;DR: Overall, this study establishes the CDK4/6–DUB3 axis as an important regulatory mechanism of breast cancer metastasis and provides a rationale for potential therapeutic interventions in the treatment of breast Cancer metastasis.
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A cell cycle-dependent BRCA1-UHRF1 cascade regulates DNA double-strand break repair pathway choice.
Haoxing Zhang,Hailong Liu,Yali Chen,Xu Yang,Panfei Wang,Tongzheng Liu,Min Deng,Bo Qin,Cristina Correia,Seung Baek Lee,Jung Jin Kim,Melanie A. Sparks,Asha Nair,Debra Evans,Krishna R. Kalari,Pumin Zhang,Liewei Wang,Zhongsheng You,Scott H. Kaufmann,Zhenkun Lou,Huadong Pei +20 more
TL;DR: It is reported that the E3 ubiquitin ligase UHRF1 directly participates in the interplay between BRCA1 and 53BP1 and is a key regulator of DSB repair choice, which is separate from its role in heterochromatin formation and epigenetic regulator.
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Deubiquitination and Activation of AMPK by USP10
Min Deng,Xu Yang,Bo Qin,Tongzheng Liu,Haoxing Zhang,Wei Guo,Seung Baek Lee,Jung Jin Kim,Jian Yuan,Huadong Pei,Liewei Wang,Zhenkun Lou +11 more
TL;DR: USP10 and AMPK form a key feedforward loop ensuring amplification of AMPK activation in response to fluctuation of cellular energy status, and it is found that ubiquitination on AMPKα blocks AM PKα phosphorylation by LKB1.
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MRE11 UFMylation promotes ATM activation.
Zhifeng Wang,Zhifeng Wang,Yamin Gong,Yamin Gong,Bin Peng,Ruifeng Shi,Ruifeng Shi,Dan Fan,Hongchang Zhao,Min Zhu,Haoxing Zhang,Zhenkun Lou,Jianwei Zhou,Wei-Guo Zhu,Yu-Sheng Cong,Xingzhi Xu,Xingzhi Xu +16 more
TL;DR: Taken together, MRE11 UFMylation promotes ATM activation, DSB repair and genome stability, and potentially serves as a therapeutic target.