H
Harald Hartweger
Researcher at Rockefeller University
Publications - 19
Citations - 2384
Harald Hartweger is an academic researcher from Rockefeller University. The author has contributed to research in topics: Antibody & Antigen. The author has an hindex of 9, co-authored 12 publications receiving 1537 citations.
Papers
More filters
Journal ArticleDOI
Convergent antibody responses to SARS-CoV-2 in convalescent individuals.
Davide F. Robbiani,Davide F. Robbiani,Christian Gaebler,Frauke Muecksch,Julio C. C. Lorenzi,Zijun Wang,Alice Cho,Marianna Agudelo,Christopher O. Barnes,Anna Gazumyan,Shlomo Finkin,Thomas Hagglof,Thiago Y. Oliveira,Charlotte Viant,Arlene Hurley,Hans Heinrich Hoffmann,Katrina G. Millard,Rhonda G. Kost,Melissa Cipolla,Kristie Gordon,Filippo Bianchini,Spencer T. Chen,Victor A. Ramos,Roshni Patel,Juan Dizon,Irina Shimeliovich,Pilar Mendoza,Harald Hartweger,Lilian Nogueira,Maggi Pack,Jill Horowitz,Fabian Schmidt,Yiska Weisblum,Eleftherios Michailidis,Alison W. Ashbrook,Eric Waltari,John E. Pak,Kathryn E. Huey-Tubman,Nicholas Koranda,Pauline R. Hoffman,Anthony P. West,Charles M. Rice,Theodora Hatziioannou,Pamela J. Bjorkman,Paul D. Bieniasz,Paul D. Bieniasz,Marina Caskey,Michel C. Nussenzweig,Michel C. Nussenzweig +48 more
TL;DR: Most convalescent plasma samples obtained from individuals who recover from COVID-19 do not contain high levels of neutralizing activity, and rare but recurring RBD-specific antibodies with potent antiviral activity were found in all individuals tested, suggesting that a vaccine designed to elicit such antibodies could be broadly effective.
Journal ArticleDOI
Antibody Affinity Shapes the Choice between Memory and Germinal Center B Cell Fates
Charlotte Viant,Georg H.J. Weymar,Georg H.J. Weymar,Amelia Escolano,Spencer T. Chen,Harald Hartweger,Melissa Cipolla,Anna Gazumyan,Michel C. Nussenzweig,Michel C. Nussenzweig +9 more
TL;DR: It is found that contemporaneously developing memory and GC B cells differ in their affinity for antigen throughout the immune response, and the polyclonal memory B cell compartment is composed of B cells that were activated during the immune responded but whose antigen binding affinity failed to support further clonal expansion in the GC.
Posted ContentDOI
Convergent Antibody Responses to SARS-CoV-2 Infection in Convalescent Individuals
Davide F. Robbiani,Christian Gaebler,Frauke Muecksch,Julio C. C. Lorenzi,Zijun Wang,Alice Cho,Marianna Agudelo,Christopher O. Barnes,Anna Gazumyan,Shlomo Finkin,Thomas Hagglof,Thiago Y. Oliveira,Charlotte Viant,Arlene Hurley,Hans-Heinrich Hoffmann,Katrina G. Millard,Rhonda G. Kost,Kristie Gordon,Melissa Cipolla,Filippo Bianchini,Spencer T. Chen,Victor A. Ramos,Roshni Patel,Juan Dizon,Irina Shimeliovich,Pilar Mendoza,Harald Hartweger,Lilian Nogueira,Maggi Pack,Jill Horowitz,Fabian Schmidt,Yiska Weisblum,Eleftherios Michailidis,Alison W. Ashbrook,Eric Waltari,John E. Pak,Kathryn E. Huey-Tubman,Nicholas Koranda,Pauline R. Hoffman,Anthony P. West,Charles M. Rice,Theodora Hatziioannou,Pamela J. Bjorkman,Paul D. Bieniasz,Paul D. Bieniasz,Marina Caskey,Michel C. Nussenzweig,Michel C. Nussenzweig +47 more
TL;DR: Rare but recurring RBD-specific antibodies with potent antiviral activity were found in all individuals tested, suggesting that a vaccine designed to elicit such antibodies could be broadly effective.
Journal ArticleDOI
Protein Amounts of the MYC Transcription Factor Determine Germinal Center B Cell Division Capacity
Shlomo Finkin,Harald Hartweger,Thiago Y. Oliveira,Ervin E. Kara,Michel C. Nussenzweig,Michel C. Nussenzweig +5 more
TL;DR: Gene expression analysis revealed that Tfh cells induce Myc expression in light-zone B cells in direct proportion to antigen capture, which constitutes the GC B cell division timer that when deregulated leads to emergence of B cell lymphoma.
Journal ArticleDOI
Structural characterization of a highly-potent V3-glycan broadly neutralizing antibody bound to natively-glycosylated HIV-1 envelope.
Christopher O. Barnes,Harry B. Gristick,Natalia T. Freund,Amelia Escolano,Artem Y. Lyubimov,Harald Hartweger,Anthony P. West,Aina E. Cohen,Michel C. Nussenzweig,Michel C. Nussenzweig,Pamela J. Bjorkman +10 more
TL;DR: The BG18-natively-glycosylated Env structures facilitate understanding of bNAb–glycan interactions critical for using V3/N332gp120 bNAbs therapeutically and targeting their epitope for immunogen design.