Harald Hartweger

TL;DR: Most convalescent plasma samples obtained from individuals who recover from COVID-19 do not contain high levels of neutralizing activity, and rare but recurring RBD-specific antibodies with potent antiviral activity were found in all individuals tested, suggesting that a vaccine designed to elicit such antibodies could be broadly effective.

TL;DR: It is found that contemporaneously developing memory and GC B cells differ in their affinity for antigen throughout the immune response, and the polyclonal memory B cell compartment is composed of B cells that were activated during the immune responded but whose antigen binding affinity failed to support further clonal expansion in the GC.

TL;DR: Rare but recurring RBD-specific antibodies with potent antiviral activity were found in all individuals tested, suggesting that a vaccine designed to elicit such antibodies could be broadly effective.

TL;DR: Gene expression analysis revealed that Tfh cells induce Myc expression in light-zone B cells in direct proportion to antigen capture, which constitutes the GC B cell division timer that when deregulated leads to emergence of B cell lymphoma.

TL;DR: The BG18-natively-glycosylated Env structures facilitate understanding of bNAb–glycan interactions critical for using V3/N332gp120 bNAbs therapeutically and targeting their epitope for immunogen design.