Hardik J. Patel

TL;DR: It is found that under conditions of stress, such as malignant transformation fuelled by MYC, the chaperome becomes biochemically ‘rewired’ to form a network of stable, survival-facilitating, high-molecular-weight complexes.

TL;DR: It is shown that Grp94 selectivity is due to the insertion of these compounds into a new allosteric pocket, and new mechanistic evidence explaining why selective Grp 94 inhibition is particularly efficacious in certain breast cancers is provided.

TL;DR: In this article, the production of laccase by an indigenous strain of Pleurotus ostreatus HP-1 on solid state fermentation was studied on a wheat straw substrate with five agar plugs as the inoculum.

TL;DR: Genetic and pharmacologic studies demonstrate that JAK2 remains an essential target in MPN cells that survive in the setting of chronic JAK inhibition, and suggest alternate approaches that increase Jak2 targeting, including combination JAK/HSP90 inhibitor therapy, are warranted in the clinical setting.

TL;DR: The significantly different phenotypic outcomes observed from HSp90 inhibition by the many inhibitors developed suggest that the clinical development of Hsp90 inhibitors would be better served by careful consideration of the pharmacokinetic/pharmacodynamic properties of individual candidates rather than a generic approach directed towards the target.