Adriana D. Corben

TL;DR: It is found that under conditions of stress, such as malignant transformation fuelled by MYC, the chaperome becomes biochemically ‘rewired’ to form a network of stable, survival-facilitating, high-molecular-weight complexes.

TL;DR: Similar in vivo redirection of STAT3 alternative splicing leads to tumor regression in a xenograft cancer model, demonstrating how pharmacological manipulation of a single key splicing event can manifest powerful antitumorigenic properties and validating endogenous splicing reprogramming as an effective cancer therapeutic approach.

TL;DR: The first 100 COVID-19-positive autopsies performed at the Mount Sinai Hospital in New York City revealed large pulmonary emboli in six cases and diffuse alveolar damage was present in over 90% of cases as mentioned in this paper.

TL;DR: In this article, the authors highlight the current status of the second-generation HSP90 inhibitors in clinical development and highlight the lessons learned from the completed clinical trials of first-and secondgeneration inhibitors and describe various assays attempting to serve for a more rational implementation of these agents to cancer treatment.

TL;DR: A proof-of-concept study demonstrated that 89Zr-trastuzumab PET/CT detects unsuspected HER2-positive metastases in patients with Her2-negative primary breast cancer, which is a proof of the concept that her2-targeted imaging can identify additional candidates for HER2 -targeted therapy.