H
Haris Mirza
Researcher at Yale University
Publications - 22
Citations - 1011
Haris Mirza is an academic researcher from Yale University. The author has contributed to research in topics: Blastocystis & Medicine. The author has an hindex of 10, co-authored 17 publications receiving 533 citations. Previous affiliations of Haris Mirza include Agency for Science, Technology and Research & National University of Singapore.
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Journal ArticleDOI
Inflammasome activation in infected macrophages drives COVID-19 pathology
Esen Sefik,Rihao Qu,Caroline Junqueira,Eleanna T. Kaffe,Haris Mirza,Jun Zhao,J. Richard Brewer,Ailin Han,Holly R. Steach,Benjamin Israelow,Holly N. Blackburn,Sofia E. Velazquez,Y. Grace Chen,Stephanie Halene,Akiko Iwasaki,Eric Meffre,Michel C. Nussenzweig,Judy Lieberman,Craig B. Wilen,Yuval Kluger,Richard A. Flavell +20 more
TL;DR: In this article , the authors showed that SARS-CoV-2 infection and replication in lung resident human macrophages is a critical driver of lung pathology, as inhibition of the NLRP3 inflammasome pathway reversed chronic lung pathology.
Journal ArticleDOI
Current Views on the Clinical Relevance of Blastocystis spp.
TL;DR: The controversial pathogenesis of Blastocystis is attributed to subtype variations in virulence; although current studies seem to support this idea, evidence suggests other factors also contribute to the clinical outcome of the infection.
Journal ArticleDOI
Inflammasome activation in infected macrophages drives COVID-19 pathology
Esen Sefik,Rihao Qu,Caroline Junqueira,Eleanna T. Kaffe,Haris Mirza,Jun Zhao,J. Richard Brewer,Ailin Han,Holly R. Steach,Benjamin Israelow,Holly N. Blackburn,Sofia E. Velazquez,Y. Grace Chen,Stephanie Halene,Akiko Iwasaki,Eric Meffre,Michel C. Nussenzweig,Judy Lieberman,Craig B. Wilen,Yuval Kluger,Richard A. Flavell +20 more
TL;DR: In this paper , the authors showed that SARS-CoV-2 infection and replication in lung resident human macrophages is a critical driver of lung pathology, as inhibition of the NLRP3 inflammasome pathway reversed chronic lung pathology.
Journal ArticleDOI
A Rapid, High-Throughput Viability Assay for Blastocystis spp. Reveals Metronidazole Resistance and Extensive Subtype-Dependent Variations in Drug Susceptibilities
TL;DR: The need to reevaluate established treatment regimens for Blastocystis infections and offer clear new treatment options for Mz treatment failures is highlighted and the first study to report extensive variations in drug sensitivities among two clinically important subtypes is reported.
Journal ArticleDOI
Blastocystis exhibits inter- and intra-subtype variation in cysteine protease activity
Haris Mirza,Kevin S. W. Tan +1 more
TL;DR: Differences in virulence between Blastocystis subtypes have been reported recently in both animal models and clinical studies, although cellular mechanisms for these differences are currently unknown.