J
Jun Zhao
Researcher at Yale University
Publications - 44
Citations - 2768
Jun Zhao is an academic researcher from Yale University. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 13, co-authored 31 publications receiving 1290 citations. Previous affiliations of Jun Zhao include Peking University & University of California, Los Angeles.
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Journal ArticleDOI
m6A mRNA methylation controls T cell homeostasis by targeting the IL-7/STAT5/SOCS pathways
Hua-Bing Li,Jiyu Tong,Jiyu Tong,Shu Zhu,Pedro J. Batista,Erin E. Duffy,Jun Zhao,Will Bailis,Guangchao Cao,Guangchao Cao,Lina Kroehling,Yuanyuan Chen,Yuanyuan Chen,Geng Wang,James P. Broughton,Y. Grace Chen,Yuval Kluger,Matthew D. Simon,Howard Y. Chang,Zhinan Yin,Richard A. Flavell,Richard A. Flavell +21 more
TL;DR: This study elucidates for the first time, to the knowledge, the in vivo biological role of m6A modification in T-cell-mediated pathogenesis and reveals a novel mechanism of T cell homeostasis and signal-dependent induction of mRNA degradation.
Journal ArticleDOI
KLRG1+ Effector CD8+ T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity.
Dietmar Herndler-Brandstetter,Harumichi Ishigame,Ryo Shinnakasu,Valerie Plajer,Carmen Stecher,Jun Zhao,Melanie Lietzenmayer,Lina Kroehling,Akiko Takumi,Kohei Kometani,Takeshi Inoue,Yuval Kluger,Susan M. Kaech,Tomohiro Kurosaki,Takaharu Okada,Richard A. Flavell +15 more
TL;DR: It is demonstrated that developmental plasticity of KLRG1+ effector CD8+ T cells is important in promoting functionally versatile memory cells and long‐term protective immunity and drives functional diversity within memory T cell lineages and promotes enhanced anti‐influenza and anti‐tumor immunity.
Journal ArticleDOI
Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells
Shu Zhu,Siyuan Ding,Siyuan Ding,Penghua Wang,Zheng Wei,Wen Pan,Noah W. Palm,Yi-Hsuan Yang,Hua Yu,Hua-Bing Li,Geng Wang,Xuqiu Lei,Marcel R. de Zoete,Jun Zhao,Yunjiang Zheng,Haiwei Chen,Yujiao Zhao,Kellie A. Jurado,Ningguo Feng,Liang Shan,Yuval Kluger,Jun Lu,Clara Abraham,Erol Fikrig,Erol Fikrig,Harry B. Greenberg,Harry B. Greenberg,Richard A. Flavell,Richard A. Flavell +28 more
TL;DR: An important innate immune signalling pathway that functions in intestinal epithelial cells and may present useful targets in the modulation of host defences against viral pathogens is highlighted.
Journal ArticleDOI
Inflammasome activation in infected macrophages drives COVID-19 pathology
Esen Sefik,Rihao Qu,Caroline Junqueira,Eleanna T. Kaffe,Haris Mirza,Jun Zhao,J. Richard Brewer,Ailin Han,Holly R. Steach,Benjamin Israelow,Holly N. Blackburn,Sofia E. Velazquez,Y. Grace Chen,Stephanie Halene,Akiko Iwasaki,Eric Meffre,Michel C. Nussenzweig,Judy Lieberman,Craig B. Wilen,Yuval Kluger,Richard A. Flavell +20 more
TL;DR: In this article , the authors showed that SARS-CoV-2 infection and replication in lung resident human macrophages is a critical driver of lung pathology, as inhibition of the NLRP3 inflammasome pathway reversed chronic lung pathology.
Journal ArticleDOI
Inflammasome activation in infected macrophages drives COVID-19 pathology
Esen Sefik,Rihao Qu,Caroline Junqueira,Eleanna T. Kaffe,Haris Mirza,Jun Zhao,J. Richard Brewer,Ailin Han,Holly R. Steach,Benjamin Israelow,Holly N. Blackburn,Sofia E. Velazquez,Y. Grace Chen,Stephanie Halene,Akiko Iwasaki,Eric Meffre,Michel C. Nussenzweig,Judy Lieberman,Craig B. Wilen,Yuval Kluger,Richard A. Flavell +20 more
TL;DR: In this paper , the authors showed that SARS-CoV-2 infection and replication in lung resident human macrophages is a critical driver of lung pathology, as inhibition of the NLRP3 inflammasome pathway reversed chronic lung pathology.