J. Richard Brewer

TL;DR: In this article , the authors showed that SARS-CoV-2 infection and replication in lung resident human macrophages is a critical driver of lung pathology, as inhibition of the NLRP3 inflammasome pathway reversed chronic lung pathology.

TL;DR: These studies support an important role for Erk1/2 as a mediator of FgF signaling in many biological processes but have also provided strong evidence for additional signaling pathways in transmitting Fgf signaling in vivo.

TL;DR: In this paper , the authors showed that SARS-CoV-2 infection and replication in lung resident human macrophages is a critical driver of lung pathology, as inhibition of the NLRP3 inflammasome pathway reversed chronic lung pathology.

TL;DR: Mechanisms through which FGF signaling regulates inner cell mass lineage restriction and cell commitment during preimplantation development are identified.

TL;DR: Analysis of each mutant indicates that Frs2 binding to Fgfr1 has the most pleiotropic functions in development but also that the receptor uses multiple proteins additively in vivo, suggesting that Erk1/2-independent signaling pathways are functionally important for Fgf signaling in vivo.