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Eleanna T. Kaffe
Publications - 8
Citations - 392
Eleanna T. Kaffe is an academic researcher. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 1, co-authored 1 publications receiving 26 citations.
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Journal ArticleDOI
Inflammasome activation in infected macrophages drives COVID-19 pathology
Esen Sefik,Rihao Qu,Caroline Junqueira,Eleanna T. Kaffe,Haris Mirza,Jun Zhao,J. Richard Brewer,Ailin Han,Holly R. Steach,Benjamin Israelow,Holly N. Blackburn,Sofia E. Velazquez,Y. Grace Chen,Stephanie Halene,Akiko Iwasaki,Eric Meffre,Michel C. Nussenzweig,Judy Lieberman,Craig B. Wilen,Yuval Kluger,Richard A. Flavell +20 more
TL;DR: In this article , the authors showed that SARS-CoV-2 infection and replication in lung resident human macrophages is a critical driver of lung pathology, as inhibition of the NLRP3 inflammasome pathway reversed chronic lung pathology.
Journal ArticleDOI
Inflammasome activation in infected macrophages drives COVID-19 pathology
Esen Sefik,Rihao Qu,Caroline Junqueira,Eleanna T. Kaffe,Haris Mirza,Jun Zhao,J. Richard Brewer,Ailin Han,Holly R. Steach,Benjamin Israelow,Holly N. Blackburn,Sofia E. Velazquez,Y. Grace Chen,Stephanie Halene,Akiko Iwasaki,Eric Meffre,Michel C. Nussenzweig,Judy Lieberman,Craig B. Wilen,Yuval Kluger,Richard A. Flavell +20 more
TL;DR: In this paper , the authors showed that SARS-CoV-2 infection and replication in lung resident human macrophages is a critical driver of lung pathology, as inhibition of the NLRP3 inflammasome pathway reversed chronic lung pathology.
Journal ArticleDOI
Oxidative stress and antioxidant status in patients with autoimmune liver diseases
Eleanna T. Kaffe,Eirini I. Rigopoulou,George K. Koukoulis,George N. Dalekos,Anargyros N. Moulas +4 more
TL;DR: Novel findings are provided in support of a major contribution of oxidant/antioxidant imbalance in the progression of liver injury in AC and AIH.
Journal ArticleDOI
Tissue resident iNKT17 cells facilitate cancer cell extravasation in liver metastasis via interleukin-22
Anastasios D. Giannou,Jan Kempski,Ahmad Mustafa Shiri,Jöran Lücke,Tao Zhang,Lilan Zhao,Dimitra E. Zazara,Filippo Cortesi,Kristoffer Riecken,Maria Carolina Amezcua Vesely,Jun Siong Low,Hao Xu,Eleanna T. Kaffe,Laura Garcia-Perez,Theodora Agalioti,Yoshito Yamada,Wolfgang Jungraithmayr,Ehud Zigmond,Karl-Frederick Karstens,Babett Steglich,John E. Wagner,Leonie Konczalla,Antonella Carambia,Kornelius Schulze,Johann von Felden,P. May,Daria Briukhovetska,Tanja Bedke,Leonie Brockmann,Sarah Starzonek,Tobias J. Lange,C Koch,Sabine Riethdorf,Penelope Pelczar,Marius Böttcher,Morsal Sabihi,Francis J. Huber,Matthias Reeh,Julia Grass,Ramez Wahib,H. E. Seese,Björn-Ole Stüben,Mohammad H Fard-Aghaie,Anna Duprée,Pasquale Scognamiglio,Gabriel Andreas Plitzko,Jan Meiners,Shiwa Soukou,Agnes Wittek,Carolin F. Manthey,Ioannis Maroulis,Petra C. Arck,Daniel Perez,Bin Gao,Sotirios G. Zarogiannis,Till Strowig,Renata Pasqualini,Wadih Arap,J. Suárez Gosálvez,Sebastian Kobold,Immo Prinz,Andreas H. Guse,Michael Tachezy,Tarik Ghadban,Asmus Heumann,Jun Li,Nathaniel Melling,Oliver Mann,Jakob R. Izbicki,Klaus Pantel,Udo Schumacher,Ansgar W. Lohse,Richard A. Flavell,Nicola Gagliani,Samuel Huber +74 more
TL;DR: In this paper , the role of interleukin (IL)-22 in metastasis was examined, and it was shown that IL-22 acted on endothelial cells, promoting endothelial permeability and cancer cell transmigration via induction of endothelial aminopeptidase N.
Journal ArticleDOI
A Treg-specific long noncoding RNA maintains immune-metabolic homeostasis in aging liver
Chenbo Ding,Esen Sefik,Jing Zhou,Eleanna T. Kaffe,Gaoyang Wang,Bin Li,Richard A. Flavell,Weiguo Hu,Youqiong Ye,Huabing Li +9 more
TL;DR: In this paper , a long non-coding RNA, Altre (aging liver Treg-expressed non-protein-Coding RNA), which was specifically expressed in the nucleus of Treg cells and increased with aging was identified.