H
Harold A. Singer
Researcher at Albany Medical College
Publications - 87
Citations - 4336
Harold A. Singer is an academic researcher from Albany Medical College. The author has contributed to research in topics: Vascular smooth muscle & Ca2+/calmodulin-dependent protein kinase. The author has an hindex of 33, co-authored 82 publications receiving 3547 citations.
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Journal ArticleDOI
Large-Scale Multi-omic Analysis of COVID-19 Severity.
Katherine A. Overmyer,Evgenia Shishkova,Ian J. Miller,Joseph Balnis,Matthew N. Bernstein,Trenton M. Peters-Clarke,Jesse G. Meyer,Qiuwen Quan,Laura K. Muehlbauer,Edna A. Trujillo,Yuchen He,Amit Chopra,Hau Chieng,Anupama Tiwari,Marc A. Judson,Brett Paulson,Dain R. Brademan,Yunyun Zhu,Lia R. Serrano,Vanessa Linke,Lisa A. Drake,Alejandro P. Adam,Bradford S Schwartz,Harold A. Singer,Scott Swanson,Deane F. Mosher,Ron Stewart,Joshua J. Coon,Ariel Jaitovich +28 more
TL;DR: A web-based tool (covid-omics.app) is presented enabling interactive exploration of the compendium and its utility through a machine learning approach for prediction of COVID-19 severity is illustrated.
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Evidence for STIM1- and Orai1-dependent store-operated calcium influx through ICRAC in vascular smooth muscle cells: role in proliferation and migration
Marie Potier,Jose C. Gonzalez,Rajender K. Motiani,Iskandar F. Abdullaev,Jonathan M. Bisaillon,Harold A. Singer,Mohamed Trebak +6 more
TL;DR: These results are the first to show ICRAC in VSMCs and resolve a long‐standing controversy by identifying CRAC as the elusive VSMC SOCE channel important for proliferation and migration.
Journal ArticleDOI
The non-excitable smooth muscle: Calcium signaling and phenotypic switching during vascular disease
TL;DR: The physiological implications of the altered expression of Ca2+ signaling molecules, their contribution to VSMC dysfunction during vascular disease and their potential as targets for drug therapy will be discussed.
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Calcium Signaling through CaMKII Regulates Hepatic Glucose Production in Fasting and Obesity
Lale Ozcan,Catherine C. L. Wong,Gang Li,Tao Xu,Utpal B. Pajvani,Sung Kyu Robin Park,Anetta Wronska,Bi-Xing Chen,Andrew R. Marks,Akiyoshi Fukamizu,Johannes Backs,Harold A. Singer,John R. Yates,Domenico Accili,Ira Tabas +14 more
TL;DR: A calcium-mediated signaling pathway involved in FoxO1 nuclear localization and hepatic glucose homeostasis is revealed, which is also involved in excessive HGP in the setting of obesity.
Journal ArticleDOI
Essential role for STIM1/Orai1-mediated calcium influx in PDGF-induced smooth muscle migration
Jonathan M. Bisaillon,Rajender K. Motiani,José C. González-Cobos,Marie Potier,Katharine E. Halligan,Wael F. Alzawahra,Margarida Barroso,Harold A. Singer,David Jourd'heuil,Mohamed Trebak +9 more
TL;DR: STIM1 and Orai1 are important components for PDGF-mediated Ca(2+) entry and migration in VSMC and are upregulated in vivo during vascular injury and provide insights linking PDGF to STIM1/Orai 1 during neointima formation.