H
Harvey Schwartz
Researcher at National Institutes of Health
Publications - 4
Citations - 156
Harvey Schwartz is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Hsp90 & Heat shock. The author has an hindex of 3, co-authored 4 publications receiving 125 citations.
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Journal ArticleDOI
HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation.
Toshiki Kijima,Thomas Prince,Megan L. Tigue,Kendrick Yim,Harvey Schwartz,Kristin Beebe,Sunmin Lee,Marek A. Budzynski,Heinric Williams,Jane B. Trepel,Lea Sistonen,Stuart K. Calderwood,Len Neckers +12 more
TL;DR: A noncanonical role for HSP90 is identified in providing dynamic modulation of HSF1 activity by participating in removal ofHSF1 trimers from heat shock elements in DNA, thus terminating the heat shock response.
Journal ArticleDOI
Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants.
Thomas Prince,Toshiki Kijima,Manabu Tatokoro,Sunmin Lee,Shinji Tsutsumi,Kendrick Yim,Candy Rivas,Sylvia V. Alarcon,Harvey Schwartz,Kofi Khamit-Kush,Bradley T. Scroggins,Kristin Beebe,Jane B. Trepel,Len Neckers +13 more
TL;DR: It is found that some clients interact strongly with a single, ATP-stabilized HSP90 conformation, only transiently populated during the dynamic H SP90 chaperone cycle, while other clients interact equally with multiple HSP 90 conformations, which suggest different functional requirements among Hsp90 clientele that, for some clients, are likely to be ATP-independent.
Journal ArticleDOI
Combined HSP90 and kinase inhibitor therapy: Insights from The Cancer Genome Atlas.
Harvey Schwartz,Brad Scroggins,Abbey D. Zuehlke,Toshiki Kijima,Kristin Beebe,Alok Mishra,Len Neckers,Thomas Prince +7 more
TL;DR: The purpose of this perspective is to reflect on the current understanding of HSP90 and kinase biology as well as promote the exploration of potential synergistic molecular therapy combinations through the utilization of The Cancer Genome Atlas.
Posted ContentDOI
HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation
Toshiki Kijima,Thomas Prince,Megan L. Tigue,Kendrick Yim,Harvey Schwartz,Kristin Beebe,Sunmin Lee,Marek A. Budzynski,Heinric Williams,Jane B. Trepel,Lea Sistonen,Stuart K. Calderwood,Len Neckers +12 more
TL;DR: A noncanonical role for HSP90 is identified in providing dynamic modulation of HSF1 activity by participating in removal ofHSF1 trimers from heat shock elements in DNA, thus terminating the heat shock response.