M
Marek A. Budzynski
Researcher at Åbo Akademi University
Publications - 15
Citations - 282
Marek A. Budzynski is an academic researcher from Åbo Akademi University. The author has contributed to research in topics: Heat shock factor & Heat shock protein. The author has an hindex of 6, co-authored 11 publications receiving 198 citations. Previous affiliations of Marek A. Budzynski include University of British Columbia.
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Journal ArticleDOI
Uncoupling Stress-Inducible Phosphorylation of Heat Shock Factor 1 from Its Activation.
TL;DR: The results provide the first direct evidence for uncoupling stress-inducible phosphorylation of HSF1 from its activation, and it is proposed that theosphorylation signature alone is not an appropriate marker forHSF1 activity.
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HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation.
Toshiki Kijima,Thomas Prince,Megan L. Tigue,Kendrick Yim,Harvey Schwartz,Kristin Beebe,Sunmin Lee,Marek A. Budzynski,Heinric Williams,Jane B. Trepel,Lea Sistonen,Stuart K. Calderwood,Len Neckers +12 more
TL;DR: A noncanonical role for HSP90 is identified in providing dynamic modulation of HSF1 activity by participating in removal ofHSF1 trimers from heat shock elements in DNA, thus terminating the heat shock response.
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Co-chaperones TIMP2 and AHA1 Competitively Regulate Extracellular HSP90:Client MMP2 Activity and Matrix Proteolysis
Alexander J. Baker-Williams,Fiza Hashmi,Marek A. Budzynski,Mark R. Woodford,Stephanie Gleicher,Samu V. Himanen,Alan M. Makedon,Derek Friedman,Stephanie Cortes,Sara Namek,William G. Stetler-Stevenson,Gennady Bratslavsky,Alaji Bah,Mehdi Mollapour,Lea Sistonen,Dimitra Bourboulia +15 more
TL;DR: The data suggest that TIMP2 and AHA1 co-chaperones function as a molecular switch that determines the inhibition and reactivation of the eHSP90 client protein MMP2.
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Heat Shock Factor 2 Protects Against Proteotoxicity by Maintaining Cell-Cell Adhesion
Jenny Joutsen,Alejandro J. Da Silva,Jens C. Luoto,Marek A. Budzynski,Anna Serafia Nylund,Aurélie de Thonel,Aurélie de Thonel,Jean-Paul Concordet,Valérie Mezger,Valérie Mezger,Délara Sabéran-Djoneidi,Délara Sabéran-Djoneidi,Eva Henriksson,Lea Sistonen +13 more
TL;DR: It is demonstrated that HSF2-dependent maintenance of cadherin-mediated cell-cell adhesion is required for protection against stress induced by proteasome inhibition and defines cell- cell adhesion as a determinant of proteotoxic stress resistance.
Journal ArticleDOI
Chaperone co-inducer BGP-15 inhibits histone deacetylases and enhances the heat shock response through increased chromatin accessibility
Marek A. Budzynski,Tim Crul,Samu V. Himanen,Noémi Tóth,Ferenc Ötvös,Lea Sistonen,László Vígh +6 more
TL;DR: This work used the chaperone co-inducer BGP-15 to lower the threshold for the heat shock response activation, and inhibited the activity of histone deacetylases (HDACs), thereby increasing chromatin accessibility at multiple genomic loci including the stress-inducible HSPA1A.