Kendrick Yim

TL;DR: A noncanonical role for HSP90 is identified in providing dynamic modulation of HSF1 activity by participating in removal ofHSF1 trimers from heat shock elements in DNA, thus terminating the heat shock response.

TL;DR: GBA, a pharmacophore contained within the natural product gambogic acid that binds uniquely to a site in Hsp90β, is identified as a prototype of a new class of isoform-specific Hsp 90 inhibitors, providing a new chemical tool to study the unique biological role of this abundantly expressed molecular chaperone in health and disease.

TL;DR: The current status and future prospects of neoadjuvant therapy in nonmetastatic renal cell carcinoma are reviewed and the advent of immunomodulation through checkpoint inhibition represents an exciting horizon for neoadedjuvant strategies.

TL;DR: It is found that some clients interact strongly with a single, ATP-stabilized HSP90 conformation, only transiently populated during the dynamic H SP90 chaperone cycle, while other clients interact equally with multiple HSP 90 conformations, which suggest different functional requirements among Hsp90 clientele that, for some clients, are likely to be ATP-independent.

TL;DR: The present article reviews the current status and future prospects of adjuvant and neoadjuvant therapy in localized and locally advanced renal cell carcinoma and discusses the advent of immunomodulation through checkpoint inhibition.