L
Len Neckers
Researcher at National Institutes of Health
Publications - 9
Citations - 228
Len Neckers is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Heat shock & Citric acid cycle. The author has an hindex of 4, co-authored 9 publications receiving 171 citations. Previous affiliations of Len Neckers include Johns Hopkins University.
Papers
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Journal ArticleDOI
HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation.
Toshiki Kijima,Thomas Prince,Megan L. Tigue,Kendrick Yim,Harvey Schwartz,Kristin Beebe,Sunmin Lee,Marek A. Budzynski,Heinric Williams,Jane B. Trepel,Lea Sistonen,Stuart K. Calderwood,Len Neckers +12 more
TL;DR: A noncanonical role for HSP90 is identified in providing dynamic modulation of HSF1 activity by participating in removal ofHSF1 trimers from heat shock elements in DNA, thus terminating the heat shock response.
Journal ArticleDOI
Selective Inhibition of HER2-Positive Breast Cancer Cells by the HIV Protease Inhibitor Nelfinavir
Joong Sup Shim,Rajini Rao,Kristin Beebe,Kristin Beebe,Len Neckers,Len Neckers,Inkyu Han,Rita Nahta,Jun O. Liu +8 more
TL;DR: Nelfinavir was found to be a new class of HSP90 inhibitor and can be brought to HER2-breast cancer treatment trials with the same dosage regimen as that used among HIV patients.
Journal ArticleDOI
The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in mitochondrial metabolic homeostasis
Abhinav Joshi,Li Dai,Yanxin Liu,Jungsoon Lee,Nastaran Mohammadi Ghahhari,Gregory Segala,Kristin Beebe,Lisa M. Miller Jenkins,Gaelyn C. Lyons,Lilia Bernasconi,Francis T.F. Tsai,David A. Agard,Len Neckers,Didier Picard +13 more
TL;DR: The disruption of the gene for TRAP1 in a panel of cell lines dysregulates OXPHOS by a metabolic rewiring that induces the anaplerotic utilization of glutamine metabolism to replenish TCA cycle intermediates.
Patent
Use of inhibitors of 3-hydroxy-3-methylglutaryl coenzyme a reductase as a modality in cancer therapy
TL;DR: Methods of treating various cancers, such as prostatic adenocarcinoma, with inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG Co-A), such as lovastatin, are provided in this article.
Posted ContentDOI
The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in maintaining mitochondrial metabolic homeostasis
Abhinav Joshi,Joyce Dai,Jungsoon Lee,Nastaran Mohammadi Ghahhari,Gregory Segala,Kristin Beebe,Francis T.F. Tsai,Len Neckers,Didier Picard +8 more
TL;DR: The disruption of the gene for TRAP1 in a panel of cell lines dysregulates OXPHOS by a metabolic rewiring that induces the anaplerotic utilization of glutamine metabolism to replenish TCA cycle intermediates, which provides a roadmap for further investigations of howTRAP1 and its interactors such as the ATP synthase regulate cellular energy metabolism.