H
Hayes M. Dansky
Researcher at Merck & Co.
Publications - 36
Citations - 2966
Hayes M. Dansky is an academic researcher from Merck & Co.. The author has contributed to research in topics: Anacetrapib & Cholesterylester transfer protein. The author has an hindex of 22, co-authored 36 publications receiving 2841 citations. Previous affiliations of Hayes M. Dansky include Icahn School of Medicine at Mount Sinai & Columbia University.
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Journal ArticleDOI
Safety of Anacetrapib in Patients with or at High Risk for Coronary Heart Disease
Christopher P. Cannon,Sukrut Shah,Hayes M. Dansky,Michael H. Davidson,Eliot A. Brinton,Antonio M. Gotto,Michael Stepanavage,Sherry Xueyu Liu,Patrice H. Gibbons,Tanya B. Ashraf,Jennifer Zafarino,Yale B. Mitchel,Philip J. Barter +12 more
TL;DR: Treatment with anacetrapib had robust effects on LDL and HDL cholesterol, had an acceptable side-effect profile, and, within the limits of the power of this study, did not result in the adverse cardiovascular effects observed with torcetrapib.
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Intensification of Statin Therapy Results in a Rapid Reduction in Atherosclerotic Inflammation: Results of a Multicenter Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography Feasibility Study
Ahmed Tawakol,Zahi A. Fayad,Robin Mogg,Achilles Alon,Michael Klimas,Hayes M. Dansky,Sharath Subramanian,Amr Abdelbaky,James H.F. Rudd,Michael E. Farkouh,Michael E. Farkouh,Irene Nunes,Chan R. Beals,Sudha S. Shankar +13 more
TL;DR: Statin therapy produced significant rapid dose-dependent reductions in FDG uptake that may represent changes in atherosclerotic plaque inflammation, and FDG-PET imaging may be useful in detecting early treatment effects in patients at risk or with established atherosclerosis.
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Noninvasive In Vivo High-Resolution Magnetic Resonance Imaging of Atherosclerotic Lesions in Genetically Engineered Mice
Zahi A. Fayad,John T. Fallon,Meir Shinnar,Suzanne Wehrli,Hayes M. Dansky,Michael Poon,Juan J. Badimon,Sherri A. Charlton,Edward A. Fisher,Jan L. Breslow,Valentin Fuster +10 more
TL;DR: The combination of high-resolution MR microscopy and genetically engineered animals is a powerful tool to investigate serially and noninvasively the progression and regression of atherosclerotic lesions in an intact animal model and should greatly enhance basic studies of atheosclerotic disease.
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Elevating high-density lipoprotein cholesterol in apolipoprotein E-deficient mice remodels advanced atherosclerotic lesions by decreasing macrophage and increasing smooth muscle cell content.
James X. Rong,Jie Li,Ernane D. Reis,Robin P. Choudhury,Hayes M. Dansky,Valerie I. Elmalem,John T. Fallon,Jan L. Breslow,Edward A. Fisher +8 more
TL;DR: Increasing HDL cholesterol levels in EKO mice retards progression of advanced atherosclerotic lesions and remodels them to a more stable-appearing phenotype.
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Recipes for Creating Animal Models of Diabetic Cardiovascular Disease
Willa A. Hsueh,E. Dale Abel,Jan L. Breslow,Nobuyo Maeda,Richard C. Davis,Edward A. Fisher,Hayes M. Dansky,Donald A. McClain,Richard A. McIndoe,Momtaz Wassef,Cristina Rabadan-Diehl,Ira J. Goldberg +11 more
TL;DR: The consortium has worked to standardize many methods to assess metabolic and cardiovascular end points for measurement of the diabetic state and its macrovascular complications and created a system for sharing both the animal models and the accumulated phenotypic data with the greater scientific community.