S
Suzanne Wehrli
Researcher at Children's Hospital of Philadelphia
Publications - 114
Citations - 7082
Suzanne Wehrli is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Galactosemia & Galactitol. The author has an hindex of 37, co-authored 114 publications receiving 6554 citations. Previous affiliations of Suzanne Wehrli include University of Wisconsin–Milwaukee & Washington University in St. Louis.
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Beyond aerobic glycolysis : Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
Ralph J. DeBerardinis,Anthony A. Mancuso,Evgueni Daikhin,Ilana Nissim,Marc Yudkoff,Suzanne Wehrli,Craig B. Thompson +6 more
TL;DR: Transformed cells exhibit a high rate of glutamine consumption that cannot be explained by the nitrogen demand imposed by nucleotide synthesis or maintenance of nonessential amino acid pools, and glutamine metabolism provides a carbon source that facilitates the cell's ability to use glucose-derived carbon and TCA cycle intermediates as biosynthetic precursors.
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Squalamine: an aminosterol antibiotic from the shark.
Karen S. Moore,Suzanne Wehrli,Heinrich Roder,Mark Rogers,John N. Forrest,Donald McCrimmon,Michael Zasloff +6 more
TL;DR: The discovery of squalamine in the shark implicates a steroid as a potential host-defense agent in vertebrates and provides insights into the chemical design of a family of broad-spectrum antibiotics.
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The Diagnostic Accuracy of Ex Vivo MRI for Human Atherosclerotic Plaque Characterization
Meir Shinnar,John T. Fallon,Suzanne Wehrli,Michael G. Levin,Dolcine Dalmacy,Zahi A. Fayad,Juan J. Badimon,Martin Harrington,Elizabeth O. Harrington,Valentin Fuster +9 more
TL;DR: MRI can characterize carotid artery plaques with a high level of sensitivity and specificity and Application of these results in the clinical setting may be feasible in the near future.
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Noninvasive In Vivo High-Resolution Magnetic Resonance Imaging of Atherosclerotic Lesions in Genetically Engineered Mice
Zahi A. Fayad,John T. Fallon,Meir Shinnar,Suzanne Wehrli,Hayes M. Dansky,Michael Poon,Juan J. Badimon,Sherri A. Charlton,Edward A. Fisher,Jan L. Breslow,Valentin Fuster +10 more
TL;DR: The combination of high-resolution MR microscopy and genetically engineered animals is a powerful tool to investigate serially and noninvasively the progression and regression of atherosclerotic lesions in an intact animal model and should greatly enhance basic studies of atheosclerotic disease.
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Magnetic resonance microimaging of intraaxonal water diffusion in live excised lamprey spinal cord
Masaya Takahashi,David B. Hackney,Guixin Zhang,Suzanne Wehrli,Alexander C. Wright,William T. O'Brien,Hidemasa Uematsu,Felix W. Wehrli,Michael E. Selzer +8 more
TL;DR: In this article, the authors used the sea lamprey spinal cord to determine whether intraaxonal diffusion is isotropic and whether anisotropy is attributable to restriction of water mobility by axon surface membranes.