H
Hayley J. Newton
Researcher at University of Melbourne
Publications - 70
Citations - 3188
Hayley J. Newton is an academic researcher from University of Melbourne. The author has contributed to research in topics: Coxiella burnetii & Legionella pneumophila. The author has an hindex of 25, co-authored 63 publications receiving 2728 citations. Previous affiliations of Hayley J. Newton include Yale University & Monash University, Clayton campus.
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Journal ArticleDOI
Molecular Pathogenesis of Infections Caused by Legionella pneumophila
TL;DR: The factors that contribute to the ability of L. pneumophila to infect and replicate in human cells and amoebae are reviewed with an emphasis on proteins that are secreted by the bacteria into the Legionella vacuole and/or the host cell.
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The type III effectors NleE and NleB from enteropathogenic E. coli and OspZ from Shigella block nuclear translocation of NF-kappaB p65
Hayley J. Newton,Jaclyn S. Pearson,Luminita Badea,Michelle Kelly,Mark Lucas,Gavan Holloway,Kylie M. Wagstaff,Michelle A. Dunstone,Joan Sloan,James C. Whisstock,James B. Kaper,Roy M. Robins-Browne,David A. Jans,Gad Frankel,Alan D. Phillips,Barbara S. Coulson,Elizabeth L. Hartland +16 more
TL;DR: Overall the data show that EPEC and Shigella have evolved similar T3SS-dependent means to manipulate host inflammatory pathways by interfering with the activation of selected host transcriptional regulators.
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Two novel point mutations in clinical Staphylococcus aureus reduce linezolid susceptibility and switch on the stringent response to promote persistent infection.
Wei Gao,Kyra Y. L. Chua,Kyra Y. L. Chua,John K. Davies,Hayley J. Newton,Torsten Seemann,Paul Harrison,Natasha E Holmes,Hyun-Woo Rhee,Jong-In Hong,Elizabeth L. Hartland,Timothy P. Stinear,Timothy P. Stinear,Benjamin P Howden +13 more
TL;DR: It is demonstrated for the first time the impact of an active stringent response in S. aureus, which was associated with reduced growth, and attenuated virulence in the Galleria mellonella model, and highlighting potential weaknesses of current antibiotic treatment regimens.
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The Coxiella burnetii Dot/Icm System Delivers a Unique Repertoire of Type IV Effectors into Host Cells and Is Required for Intracellular Replication
TL;DR: Data indicate that C. burnetii encodes a unique subset of bacterial effector proteins translocated into host cells by the Dot/Icm apparatus, and that the cumulative activities exerted by these effectors enables C.Burnetii to successfully establish a niche inside mammalian cells that supports intracellular replication.
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Analysis of the Legionella longbeachae Genome and Transcriptome Uncovers Unique Strategies to Cause Legionnaires' Disease
Christel Cazalet,Laura Gomez-Valero,Christophe Rusniok,Mariella Lomma,Delphine Dervins-Ravault,Hayley J. Newton,Fiona M. Sansom,Sophie Jarraud,Nora Zidane,Laurence Ma,Christiane Bouchier,Jerome Etienne,Elizabeth L. Hartland,Carmen Buchrieser +13 more
TL;DR: Sequencing and analysis of four L. longbeachae genomes revealed species-specific differences that may account for the different environmental niches and disease epidemiology of these two Legionella species, including a less pronounced biphasic life cycle as compared to L. pneumophila.