H
He Changsheng
Researcher at South China University of Technology
Publications - 7
Citations - 39
He Changsheng is an academic researcher from South China University of Technology. The author has contributed to research in topics: Reporter gene & Expression vector. The author has an hindex of 2, co-authored 7 publications receiving 11 citations.
Papers
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Journal ArticleDOI
Rapid and accurate detection of SARS-CoV-2 mutations using a Cas12a-based sensing platform
He Changsheng,Cailing Lin,Guosheng Mo,Binbin Xi,An′an Li,Dongchao Huang,Yanbin Wan,Feng Chen,Yufeng Liang,Qingxia Zuo,Wanqing Xu,Dongyan Feng,Guanting Zhang,Liya Han,Changwen Ke,Hongli Du,Lizhen Huang +16 more
TL;DR: In this paper, a Cas12a-based RT-PCR combined with CRISPR on-site rapid detection system (RT-CORDS) platform was used to detect the key mutations in SARS-CoV-2 variants, such as 69/70 deletion, N501Y, and D614G.
Journal ArticleDOI
Advancing the predictivity of skin sensitization by applying a novel HMOX1 reporter system.
Guorui Zhong,Li Haojian,Bai Jing,Pang Shihui,He Changsheng,Du Xinyi,Wang Haijie,Zhang Qixiao,Shuilin Xie,Hongli Du,Renke Dai,Lizhen Huang +11 more
TL;DR: EndoSens was developed, whereby luciferase was specifically inserted into the cassette for heme oxygenase (decycling) 1 (HMOX1, the most consistent marker induced by skin sensitizers) by CRISPR/Cas9, indicating that the EndoSens assay could advance the predictivity of skin sensitization, thus making it a promising tool for in vitro skin sensitized testing.
Patent
In-vitro evaluation cell model of skin sensitization of compound and construction method of cell model
Lizhen Huang,Guorui Zhong,Li Haojian,Xie Shuilin,Pang Shihui,Bai Jing,He Changsheng,Du Xinyi,Zhang Qixiao,Wang Haijie,Du Hongli +10 more
TL;DR: In this article, an in-vitro evaluation cell model of skin sensitization of a compound and a construction method of the cell model are presented. But the method is not suitable for compound sensitization studies.
Journal ArticleDOI
Improved defined approaches for predicting skin sensitization hazard and potency in humans.
TL;DR: Improved DAs in this study showed higher performance than LLNA and other machine-learning-based DAs, and the potency-DA could provide more in-depth assessment, and could be promising tools for skin sensitization assessment without animal testing.
Patent
On-site rapid detection method and kit for detecting PRRSV
Lizhen Huang,Haosi Lin,Guorui Zhong,Li Haojian,Du Hongli,Bai Jing,He Changsheng,Shuilin Xie,Renke Dai +8 more
TL;DR: In this article, an on-site rapid detection method and kit for detecting PRRSV was presented, which utilizes the specificity of crRNA and RPA primers to effectively guarantee the virus detection accurateness, and within 1-2h at room temperature, whether the virus is infected and the subtype of the infected PRRSVs can be determined by test paper.