H
Hedwig Stanisz
Researcher at University of Göttingen
Publications - 16
Citations - 428
Hedwig Stanisz is an academic researcher from University of Göttingen. The author has contributed to research in topics: Melanoma & Medicine. The author has an hindex of 8, co-authored 11 publications receiving 315 citations. Previous affiliations of Hedwig Stanisz include Saarland University.
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Journal ArticleDOI
Inverse regulation of melanoma growth and migration by Orai1/STIM2‐dependent calcium entry
Hedwig Stanisz,Stephanie Saul,Cornelia S. L. Müller,Reinhard Kappl,Barbara A. Niemeyer,Thomas Vogt,Markus Hoth,Alexander Roesch,Ivan Bogeski +8 more
TL;DR: A dynamic model in which Orai1 and STIM2 inversely control melanoma growth and invasion is supported, which might prevent metastatic spread and render melanomas more susceptible to conventional therapy.
Journal ArticleDOI
The role of the mitochondrial calcium uniporter (MCU) complex in cancer.
TL;DR: Current knowledge on the role of the mitochondrial calcium uniporter (MCU) complex in multiple cancer types and models is reviewed and a perspective for future research and clinical considerations is provided.
Journal ArticleDOI
ORAI1 Ca2+ Channels Control Endothelin-1-Induced Mitogenesis and Melanogenesis in Primary Human Melanocytes
Hedwig Stanisz,Alexandra Stark,Tatiana Kilch,Eva C. Schwarz,Cornelia S. L. Müller,Christine Peinelt,Markus Hoth,Barbara A. Niemeyer,Thomas Vogt,Ivan Bogeski +9 more
TL;DR: In this article, the authors showed that ORAI1 and their activating partners stromal interaction molecules 1 and 2 (STIM1 and STIM2) are expressed in human melanocytes.
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A calcium-redox feedback loop controls human monocyte immune responses: The role of ORAI Ca2+ channels.
Stephanie Saul,Christine S Gibhardt,Barbara Schmidt,Annette Lis,Bastian Pasieka,David Conrad,Philipp Jung,Rosmarie Gaupp,Bodo Wonnenberg,Ebru Diler,Hedwig Stanisz,Thomas Vogt,Eva C. Schwarz,Markus Bischoff,Mathias Herrmann,Thomas Tschernig,Reinhard Kappl,Heiko Rieger,Barbara A. Niemeyer,Ivan Bogeski +19 more
TL;DR: The results identified the ORAI-NOX2 feedback loop as a determinant of monocyte immune responses and generated a mathematical model that predicted additional features of the Ca2+-redox interplay.
Journal ArticleDOI
Redox signals at the ER-mitochondria interface control melanoma progression.
Xin Zhang,Xin Zhang,Christine S Gibhardt,Thorsten Will,Hedwig Stanisz,Christina Körbel,Miso Mitkovski,Ioana Stejerean,Sabrina Cappello,David Pacheu-Grau,Jan Dudek,Nasser Tahbaz,Lucas Mina,Thomas Simmen,Matthias W. Laschke,Michael D. Menger,Michael P. Schön,Volkhard Helms,Barbara A. Niemeyer,Peter Rehling,Peter Rehling,Adina Vultur,Ivan Bogeski,Ivan Bogeski +23 more
TL;DR: This study unravels a novel redox‐controlled ER–mitochondria–NFAT1 signaling loop that regulates melanoma pathobiology and provides biomarkers indicative of aggressive disease.