J
Jan Dudek
Researcher at University of Göttingen
Publications - 30
Citations - 2361
Jan Dudek is an academic researcher from University of Göttingen. The author has contributed to research in topics: Mitochondrion & Respiratory chain. The author has an hindex of 19, co-authored 30 publications receiving 1980 citations. Previous affiliations of Jan Dudek include University of Freiburg.
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Journal ArticleDOI
Mitochondrial presequence translocase: switching between TOM tethering and motor recruitment involves Tim21 and Tim17.
Agnieszka Chacinska,Maria I. Lind,Maria I. Lind,Ann E. Frazier,Jan Dudek,Chris Meisinger,Andreas Geissler,Albert Sickmann,Helmut E. Meyer,Kaye N. Truscott,Kaye N. Truscott,Bernard Guiard,Nikolaus Pfanner,Peter Rehling +13 more
TL;DR: The presequence translocase is not a static complex but switches between TOM tethering and PAM binding in a reaction cycle involving Tim21 and Tim17, which is crucial for the switch of protein translocation into the matrix.
Journal ArticleDOI
Role of Cardiolipin in Mitochondrial Signaling Pathways.
TL;DR: The role of CL in cellular signaling pathways is summarized and focus on tissues with high-energy demand, like the heart, and the signaling pathways described here may play a general role in pathology.
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Mitochondrial protein import: common principles and physiological networks
TL;DR: Recent studies that indicate how the pathways for mitochondrial protein biogenesis are embedded into a functional network of various other physiological processes, such as energy metabolism, signal transduction, and maintenance of mitochondrial morphology are discussed.
Journal ArticleDOI
A J-protein is an essential subunit of the presequence translocase–associated protein import motor of mitochondria
Kaye N. Truscott,Wolfgang Voos,Ann E. Frazier,Maria I. Lind,Yanfeng Li,Andreas Geissler,Jan Dudek,Hanne Müller,Albert Sickmann,Albert Sickmann,Helmut E. Meyer,Chris Meisinger,Bernard Guiard,Peter Rehling,Nikolaus Pfanner +14 more
TL;DR: The reaction cycle of the PAM of mitochondria involves an essential J-protein, an essential inner membrane protein of 18 kD with a J-domain that stimulates the ATPase activity of mtHsp70 and protein translocation into the matrix.
Journal ArticleDOI
Pam16 has an essential role in the mitochondrial protein import motor
Ann E. Frazier,Jan Dudek,Bernard Guiard,Wolfgang Voos,Yanfeng Li,Maria I. Lind,Maria I. Lind,Chris Meisinger,Andreas Geissler,Andreas Geissler,Albert Sickmann,Albert Sickmann,Helmut E. Meyer,Virginia Bilanchone,M G Cumsky,Kaye N. Truscott,Nikolaus Pfanner,Peter Rehling +17 more
TL;DR: Pam16 is a newly identified type of motor subunit and is required to promote a functional PAM reaction cycle, thereby driving preprotein import into the matrix.