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Heinz-Joachim Meencke

Researcher at Humboldt University of Berlin

Publications -  23
Citations -  1504

Heinz-Joachim Meencke is an academic researcher from Humboldt University of Berlin. The author has contributed to research in topics: Epilepsy & Epilepsy surgery. The author has an hindex of 16, co-authored 22 publications receiving 1266 citations.

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Journal ArticleDOI

Histopathological Findings in Brain Tissue Obtained during Epilepsy Surgery.

Ingmar Blümcke, +74 more
TL;DR: In patients with drug‐resistant focal epilepsy requiring surgery, hippocampal sclerosis was the most common histopathological diagnosis among adults, and focal cortical dysplasia was the second most common lesion in both groups.
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Stimulus and Potassium-Induced Epileptiform Activity in the Human Dentate Gyrus from Patients with and without Hippocampal Sclerosis

TL;DR: In granule cell populations of hippocampal slices from TLE patients, high K+-induced seizure-like activity and ictal spiking coincide with basic electrophysiological abnormalities, hippocampal sclerosis, and mossy fiber sprouting, suggesting that network reorganization could play a crucial role in determining type and threshold of such activity.
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Effects of barium on stimulus-induced rises of [K+]o in human epileptic non-sclerotic and sclerotic hippocampal area CA1

TL;DR: A significant contribution of glial barium‐sensitive K+‐channels to K-buffering in non‐AHS tissue and an impairment of glia barium-sensitive K +‐uptake in AHS tissue are suggested.
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Towards a clinico-pathological classification of granule cell dispersion in human mesial temporal lobe epilepsies.

TL;DR: A clinico-pathological classification of DG pathology is proposed based on the examination of 96 surgically resected hippocampal specimens obtained from patients with chronic temporal lobe epilepsy (TLE) and a significant association between DG pathology patterns and higher age at epilepsy surgery is revealed.
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Alterations of neuronal connectivity in area CA1 of hippocampal slices from temporal lobe epilepsy patients and from pilocarpine-treated epileptic rats.

TL;DR: Neuronal network reorganization might be involved in epileptogenesis in human and rat limbic epilepsy and sprouting in area CA1 was studied because this region is most affected in human temporal lobe epilepsy.