scispace - formally typeset
H

Holger Lerche

Researcher at University of Tübingen

Publications -  217
Citations -  11502

Holger Lerche is an academic researcher from University of Tübingen. The author has contributed to research in topics: Epilepsy & Medicine. The author has an hindex of 46, co-authored 185 publications receiving 9179 citations. Previous affiliations of Holger Lerche include University of Ulm & German Center for Neurodegenerative Diseases.

Papers
More filters
Journal ArticleDOI

Analysis of shared heritability in common disorders of the brain

Verneri Anttila, +720 more
- 22 Jun 2018 - 
TL;DR: It is demonstrated that, in the general population, the personality trait neuroticism is significantly correlated with almost every psychiatric disorder and migraine, and it is shown that both psychiatric and neurological disorders have robust correlations with cognitive and personality measures.
Journal ArticleDOI

Incidence and mechanisms of cardiorespiratory arrests in epilepsy monitoring units (MORTEMUS): A retrospective study

Philippe Ryvlin, +27 more
- 01 Oct 2013 - 
TL;DR: Cardiorespiratory data showed a consistent and previously unrecognised pattern whereby rapid breathing developed after secondary generalised tonic-clonic seizure, followed within 3 min by transient or terminal cardiore Spiratory dysfunction, probably aggravated by suboptimum supervision and possibly by antiepileptic drug withdrawal.
Journal ArticleDOI

Histopathological Findings in Brain Tissue Obtained during Epilepsy Surgery.

Ingmar Blümcke, +74 more
- 25 Oct 2017 - 
TL;DR: In patients with drug‐resistant focal epilepsy requiring surgery, hippocampal sclerosis was the most common histopathological diagnosis among adults, and focal cortical dysplasia was the second most common lesion in both groups.
Journal ArticleDOI

Genetic and phenotypic heterogeneity suggest therapeutic implications in SCN2A-related disorders.

Markus Wolff, +86 more
- 01 May 2017 - 
TL;DR: Clinical and experimental data suggest a correlation between age at disease onset, response to sodium channel blockers and the functional properties of mutations in children with SCN2A-related epilepsy, and suggest that mutations associated with early infantile epilepsy result in increased sodium channel activity with gain-of-function.
Journal ArticleDOI

Mutations in GRIN2A cause idiopathic focal epilepsy with rolandic spikes

Johannes R. Lemke, +73 more
- 01 Sep 2013 - 
TL;DR: Results establish alterations of the gene encoding the NMDA receptor NR2A subunit as a major genetic risk factor for IFE.