H
Heinz Sill
Researcher at Medical University of Graz
Publications - 195
Citations - 5403
Heinz Sill is an academic researcher from Medical University of Graz. The author has contributed to research in topics: Myeloid leukemia & Leukemia. The author has an hindex of 37, co-authored 186 publications receiving 4621 citations. Previous affiliations of Heinz Sill include University of Graz & Hammersmith Hospital.
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Journal ArticleDOI
Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing
Ellen Heitzer,Martina Auer,Christin Gasch,Martin Pichler,Peter Ulz,Eva M. Hoffmann,Sigurd Lax,Julie Waldispuehl-Geigl,Oliver Mauermann,Carolin Lackner,Gerald Höfler,Florian Eisner,Heinz Sill,Hellmut Samonigg,Klaus Pantel,Sabine Riethdorf,Thomas Bauernhofer,Jochen B. Geigl,Michael R. Speicher +18 more
TL;DR: This study paves the way to use CTCs as a liquid biopsy in patients with cancer, providing more effective options to monitor tumor genomes that are prone to change during progression, treatment, and relapse.
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PTEN Is Inversely Correlated With the Cell Survival Factor Akt/PKB and Is Inactivated Via Multiple Mechanisms in Haematological Malignancies
Patricia L. M. Dahia,Ricardo C.T. Aguiar,John A. Alberta,Jennifer B. Kum,Stacey Caron,Heinz Sill,Deborah J. Marsh,Jerome Ritz,Arnold S. Freedman,Charles D. Stiles,Charis Eng +10 more
TL;DR: The finding that PTEN levels inversely correlate with phosphorylated Akt supports the hypothesis thatPTEN regulates PtdIns(3,4,5)P3 and suggests a role for PTEN in apoptosis.
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Homozygous Deletions of the p16 Tumor-Suppressor Gene Are Associated With Lymphoid Transformation of Chronic Myeloid Leukemia
TL;DR: It is concluded that functional elimination of the p16 gene, or a closely mapping gene, is involved in a significant number of patients with CML in lymphoid transformation.
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BAALC, the human member of a novel mammalian neuroectoderm gene lineage, is implicated in hematopoiesis and acute leukemia
Stephan M. Tanner,Jamie L. Austin,Gustavo Leone,Laura J. Rush,Christoph Plass,Kristiina Heinonen,Krzysztof Mrózek,Heinz Sill,Sakari Knuutila,Jonathan E. Kolitz,Kellie J. Archer,Michael A. Caligiuri,Clara D. Bloomfield,Albert de la Chapelle +13 more
TL;DR: The data suggest that BAALC is a gene implicated in both neuroectodermal and hematopoietic cell functions, suggesting a key role in the cytoskeleton network of leukemia.
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Prolonged monitoring of troponin T for the detection of anthracycline cardiotoxicity in adults with hematological malignancies
Holger W. Auner,Christoph Tinchon,Werner Linkesch,A. Tiran,Franz Quehenberger,Hartmut Link,Heinz Sill +6 more
TL;DR: Serial measurement of serum cTnT reveals delayed subclinical myocardial damage even after minor anthracycline exposure, may identify patients at risk for subsequent myocardia dysfunction, and suggests prolonged damage to the cardiac myofibrillar system.