O
Oliver Mauermann
Researcher at University of Hamburg
Publications - 12
Citations - 1633
Oliver Mauermann is an academic researcher from University of Hamburg. The author has contributed to research in topics: Circulating tumor cell & Cancer. The author has an hindex of 11, co-authored 12 publications receiving 1476 citations.
Papers
More filters
Journal ArticleDOI
Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing
Ellen Heitzer,Martina Auer,Christin Gasch,Martin Pichler,Peter Ulz,Eva M. Hoffmann,Sigurd Lax,Julie Waldispuehl-Geigl,Oliver Mauermann,Carolin Lackner,Gerald Höfler,Florian Eisner,Heinz Sill,Hellmut Samonigg,Klaus Pantel,Sabine Riethdorf,Thomas Bauernhofer,Jochen B. Geigl,Michael R. Speicher +18 more
TL;DR: This study paves the way to use CTCs as a liquid biopsy in patients with cancer, providing more effective options to monitor tumor genomes that are prone to change during progression, treatment, and relapse.
Journal ArticleDOI
Hematogenous dissemination of glioblastoma multiforme
Carolin Müller,Johannes Holtschmidt,Martina Auer,Ellen Heitzer,Katrin Lamszus,Alexander Schulte,Jakob Matschke,Sabine Langer-Freitag,Christin Gasch,Malgorzata Stoupiec,Oliver Mauermann,Sven Peine,Markus Glatzel,Michael R. Speicher,Jochen B. Geigl,Manfred Westphal,Klaus Pantel,Sabine Riethdorf +17 more
TL;DR: It is demonstrated that hematogenous GBM spread is an intrinsic feature of GBM biology and should not be allowed to serve as organ donors.
Journal ArticleDOI
Heterogeneity of Epidermal Growth Factor Receptor Status and Mutations of KRAS/PIK3CA in Circulating Tumor Cells of Patients with Colorectal Cancer
Christin Gasch,Thomas Bauernhofer,Martin Pichler,Sabine Langer-Freitag,Matthias Reeh,Adrian M. Seifert,Oliver Mauermann,Jakob R. Izbicki,Klaus Pantel,Sabine Riethdorf +9 more
TL;DR: Molecular characterization of single CTCs demonstrated considerable intra- and interpatient heterogeneity of EGFR expression and genetic alterations in EGFR, KRAS, and PIK3CA, possibly explaining the variable response rates to EGFR inhibition in patients with CRC.
Journal ArticleDOI
Establishment of tumor‐specific copy number alterations from plasma DNA of patients with cancer
Ellen Heitzer,Martina Auer,Eva M. Hoffmann,Martin Pichler,Christin Gasch,Peter Ulz,Sigurd Lax,Julie Waldispuehl-Geigl,Oliver Mauermann,Sumitra Mohan,Gunda Pristauz,Carolin Lackner,Gerald Höfler,Florian Eisner,Edgar Petru,Heinz Sill,Hellmut Samonigg,Klaus Pantel,Sabine Riethdorf,Thomas Bauernhofer,Jochen B. Geigl,Michael R. Speicher +21 more
TL;DR: This work determined the plasma DNA size distribution and the fraction of mutated plasma DNA fragments with deep sequencing and an ultrasensitive mutation‐detection method, and described a biphasic distribution in a surprisingly high proportion of cancer patients, which may have important implications for tumor diagnosis and monitoring.
Journal ArticleDOI
The dynamic range of circulating tumor DNA in metastatic breast cancer.
Maryam Heidary,Martina Auer,Peter Ulz,Ellen Heitzer,Edgar Petru,Christin Gasch,Sabine Riethdorf,Oliver Mauermann,Ingrid Lafer,Gunda Pristauz,Sigurd Lax,Klaus Pantel,Jochen B. Geigl,Michael R. Speicher +13 more
TL;DR: The dynamic range of cTDNA varies substantially in patients with metastatic breast cancer, which has important implications for the use of ctDNA as a predictive and prognostic biomarker.