H
Helen Sabzevari
Researcher at National Institutes of Health
Publications - 55
Citations - 3899
Helen Sabzevari is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Cytotoxic T cell & CD8. The author has an hindex of 29, co-authored 49 publications receiving 3683 citations. Previous affiliations of Helen Sabzevari include Scripps Research Institute.
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Journal ArticleDOI
Inhibition of CD4+25+ T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide
M. E. Christine Lutsiak,Roshanak Tolouei Semnani,Roberto De Pascalis,Syed V. S. Kashmiri,Jeffrey Schlom,Helen Sabzevari +5 more
TL;DR: This is the first report demonstrating that CY, in addition to decreasing cell number, inhibits the suppressive capability of T(REGs), and the relevance of the loss of suppressor functionality and the changes in gene expression are discussed.
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IL-2-induced activation-induced cell death is inhibited in IL-15 transgenic mice.
Joanna Marks-Konczalik,Sigrid Dubois,Jacqueline M. Losi,Helen Sabzevari,Nobuo Yamada,Lionel Feigenbaum,Thomas A. Waldmann,Yutaka Tagaya +7 more
TL;DR: IL-15 seems to contribute to enhanced immune memory by selectively propagating memory T cells and by blocking T cell death mediated by IL-2.
Journal Article
A triad of costimulatory molecules synergize to amplify T-cell activation.
James W. Hodge,Helen Sabzevari,Alicia Gómez Yafal,Linda Gritz,Matthias G.O. Lorenz,Jeffrey Schlom +5 more
TL;DR: Experiments using a four-gene construct showed that TRICOM recombinants can enhance antigen-specific T-cell responses in vivo, and demonstrate for the first time the ability of vectors to introduce three costimulatory molecules into cells, thereby activating both CD4+ and CD8+ T- cell populations to levels greater than those achieved with the use of only one or two costimulation molecules.
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Role of trans-cellular IL-15 presentation in the activation of NK cell-mediated killing, which leads to enhanced tumor immunosurveillance.
Hisataka Kobayashi,Sigrid Dubois,Noriko Sato,Helen Sabzevari,Yoshio Sakai,Thomas A. Waldmann,Yutaka Tagaya +6 more
TL;DR: Evidence is provided that the IL-15 trans-presentation mechanism operates in vivo to augment the tumor immune surveillance mechanism and provides the scientific basis for a novel strategy to prevent cancer development/metastasis.
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An Anti–Transforming Growth Factor β Antibody Suppresses Metastasis via Cooperative Effects on Multiple Cell Compartments
Jeong-Seok Nam,Masaki Terabe,Mizuko Mamura,Mizuko Mamura,Mi Jin Kang,Helen Chae,Christina H. Stuelten,Ethan A. Kohn,Binwu Tang,Helen Sabzevari,Miriam R. Anver,Scott M. Lawrence,David Danielpour,Scott Lonning,Jay A. Berzofsky,Lalage M. Wakefield +15 more
TL;DR: It is shown that efficacy of the anti-TGF-beta antibody 1D11 in suppressing metastasis was dependent on a synergistic combination of effects on both the tumor parenchyma and microenvironment and the absence of a major effect of TGF- beta antagonism on any one cell compartment may be critical for a good therapeutic window and the avoidance of autoimmune complications.