Journal ArticleDOI
Inhibition of CD4+25+ T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide
M. E. Christine Lutsiak,Roshanak Tolouei Semnani,Roberto De Pascalis,Syed V. S. Kashmiri,Jeffrey Schlom,Helen Sabzevari +5 more
TLDR
This is the first report demonstrating that CY, in addition to decreasing cell number, inhibits the suppressive capability of T(REGs), and the relevance of the loss of suppressor functionality and the changes in gene expression are discussed.About:
This article is published in Blood.The article was published on 2005-04-01. It has received 889 citations till now. The article focuses on the topics: FOXP3 & Immune system.read more
Citations
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Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer
Eiichi Sato,Sara H. Olson,Jiyoung Ahn,Brian N. Bundy,Hiroyoshi Nishikawa,Feng Qian,Achim A. Jungbluth,Denise Frosina,Sacha Gnjatic,Christine B. Ambrosone,James L. Kepner,Tosin Odunsi,Gerd Ritter,Shashikant Lele,Yao-Tseng Chen,Haruo Ohtani,Lloyd J. Old,Kunle Odunsi +17 more
TL;DR: It is concluded that intraepithelial CD8+ TILs and a high CD8-/Treg ratio are associated with favorable prognosis in epithelial ovarian cancer.
Journal ArticleDOI
Regulatory T cells, tumour immunity and immunotherapy
TL;DR: The nature and characteristics of regulatory T cells in the tumour microenvironment and their potential multiple suppressive mechanisms are considered.
Journal ArticleDOI
Immunological aspects of cancer chemotherapy.
Laurence Zitvogel,Lionel Apetoh,Lionel Apetoh,François Ghiringhelli,Guido Kroemer,Guido Kroemer +5 more
TL;DR: It is proposed that future successes in the fight against cancer will rely on the development and clinical application of combined chemo- and immunotherapies.
Journal ArticleDOI
Metronomic cyclophosphamide regimen selectively depletes CD4+CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patients
François Ghiringhelli,Cédric Ménard,Pierre Emmanuel Puig,Sylvain Ladoire,Stephan Roux,François Martin,Eric Solary,Axel Le Cesne,Laurence Zitvogel,Bruno Chauffert +9 more
TL;DR: Oral administration of metronomic cyclophosphamide in advanced cancer patients induces a profound and selective reduction of circulating regulatory T cells, associated with a suppression of their inhibitory functions on conventional T cells and NK cells leading to a restoration of peripheral T cell proliferation and innate killing activities.
Journal ArticleDOI
Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin–cyclophosphamide chemotherapy
C. Marcela Diaz-Montero,Mohamed L. Salem,Michael I. Nishimura,Elizabeth Garrett-Mayer,David J. Cole,Alberto J. Montero +5 more
TL;DR: Testing the hypothesis that circulating MDSC levels correlate with clinical cancer stage, CTX-based chemotherapy, and metastatic tumor burden found that this information must be incorporated into the design of future trials exploring immune-based therapeutic strategies.
References
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Journal ArticleDOI
Control of Regulatory T Cell Development by the Transcription Factor Foxp3
TL;DR: Foxp3, which encodes a transcription factor that is genetically defective in an autoimmune and inflammatory syndrome in humans and mice, is specifically expressed in naturally arising CD4+ regulatory T cells and retroviral gene transfer of Foxp3 converts naïve T cells toward a regulatory T cell phenotype similar to that of naturally occurring CD4+.
Journal ArticleDOI
Foxp3 programs the development and function of CD4 + CD25 + regulatory T cells
TL;DR: It is reported that the forkhead transcription factor Foxp3 is specifically expressed in CD4+CD25+ regulatory T cells and is required for their development and function and ectopic expression ofFoxp3 confers suppressor function on peripheral CD4-CD25− T cells.
Journal ArticleDOI
Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.
TL;DR: The authors showed that CD4+CD25+ cells contribute to maintaining self-tolerance by downregulating immune response to self and non-self Ags in an Ag-nonspecific manner, presumably at the T cell activation stage.
Journal ArticleDOI
An essential role for Scurfin in CD4+CD25+ T regulatory cells.
TL;DR: It is shown that Foxp3 is highly expressed by TR cells and is associated with TR cell activity and phenotype, indicating that the Scurfin and CTLA-4 pathways may intersect and providing further insight into the TR cell lineage.
Journal ArticleDOI
CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production
TL;DR: Data support the concept that the CD4+CD25+ T cells in normal mice may represent a distinct lineage of “professional” suppressor cells.
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