Helen Sabzevari

TL;DR: This is the first report demonstrating that CY, in addition to decreasing cell number, inhibits the suppressive capability of T(REGs), and the relevance of the loss of suppressor functionality and the changes in gene expression are discussed.

TL;DR: IL-15 seems to contribute to enhanced immune memory by selectively propagating memory T cells and by blocking T cell death mediated by IL-2.

TL;DR: Experiments using a four-gene construct showed that TRICOM recombinants can enhance antigen-specific T-cell responses in vivo, and demonstrate for the first time the ability of vectors to introduce three costimulatory molecules into cells, thereby activating both CD4+ and CD8+ T- cell populations to levels greater than those achieved with the use of only one or two costimulation molecules.

TL;DR: Evidence is provided that the IL-15 trans-presentation mechanism operates in vivo to augment the tumor immune surveillance mechanism and provides the scientific basis for a novel strategy to prevent cancer development/metastasis.

TL;DR: It is shown that efficacy of the anti-TGF-beta antibody 1D11 in suppressing metastasis was dependent on a synergistic combination of effects on both the tumor parenchyma and microenvironment and the absence of a major effect of TGF- beta antagonism on any one cell compartment may be critical for a good therapeutic window and the avoidance of autoimmune complications.