H
Helga B. Landsverk
Researcher at Oslo University Hospital
Publications - 5
Citations - 59
Helga B. Landsverk is an academic researcher from Oslo University Hospital. The author has contributed to research in topics: RNA polymerase II & Cell cycle checkpoint. The author has an hindex of 2, co-authored 5 publications receiving 23 citations.
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Journal ArticleDOI
WDR82/PNUTS-PP1 prevents transcription-replication conflicts by promoting RNA POLYMERASE II degradation on chromatin
Helga B. Landsverk,Lise E. Sandquist,Lilli T. E. Bay,Barbara Steurer,Coen Campsteijn,Ole J. B. Landsverk,Jurgen A. Marteijn,Eva Petermann,Laura Trinkle-Mulcahy,Randi G. Syljuåsen +9 more
TL;DR: It is suggested thatRNAPII-CTD dephosphorylation is required for the continuous turnover of RNAPII on chromatin, thereby preventing T-R conflicts.
Journal ArticleDOI
Regulation of ATR activity via the RNA polymerase II associated factors CDC73 and PNUTS-PP1.
Helga B. Landsverk,Lise E. Sandquist,Sree Rama Chaitanya Sridhara,Gro Elise Rødland,João C. Sabino,Sérgio F. de Almeida,Beáta Grallert,Laura Trinkle-Mulcahy,Randi G. Syljuåsen +8 more
TL;DR: It is shown that ATR signaling is increased after depletion of the RNAPII phosphatase PNUTS-PP1, which dephosphorylates RNAP II in its carboxy-terminal domain (CTD), and a novel pathway involvingRNAPII, CDC73 and PNutS- PP1 in ATR signaled and new insight is given into the diverse functions of ATR.
Journal ArticleDOI
Expanding roles of cell cycle checkpoint inhibitors in radiation oncology.
Sissel Hauge,Adrian Eek Mariampillai,Gro Elise Rødland,Lilli T. E. Bay,Helga B. Landsverk,Randi G. Syljuåsen +5 more
TL;DR: The WEE1, CHK1, and ATR kinases are key factors in cell cycle checkpoint regulation and are essential for checkpoint regulation as discussed by the authors, however, they are not essential for activation.
Posted ContentDOI
Regulation of ATR activity by the RNA polymerase II phosphatase PNUTS-PP1
Helga B. Landsverk,Lise E. Sandquist,Gro Elise Rødland,Beáta Grallert,Laura Trinkle-Mulcahy,Randi G. Syljuåsen +5 more
TL;DR: It is shown that ATR signaling is increased in human cells after depletion of the RNAPII phosphatase PNUTS-PP1, which dephosphorylates RNAP II on Ser 5 of its carboxy-terminal domain (CTD) (pRNAPII S5).
Journal ArticleDOI
New link between the RNA polymerase II-CTD and replication stress
TL;DR: The authors showed that proper dephosphorylation of Serine 5 in the carboxy-terminal domain (CTD) of DNA-directed RNA polymerase II subunit RPB1 is needed to prevent conflicts between transcription and replication in human cells.